Title:
PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2022/260441
Kind Code:
A1
Abstract:
This invention relates to compounds which are microtubule associated serine/threonine-like kinase (MASTL) inhibitors and the use of the compounds in the treatment of diseases and medical conditions mediated by MASTL, for example in the treatment of cancer and other target related diseases.
Inventors:
BAEK KI SEON (KR)
KHOO JA HEOUK (KR)
CHOI SOONGYU (KR)
PARK YOUNG WHAN (KR)
WARD SIMON (GB)
LE GRAND DARREN (GB)
WEST RYAN (GB)
TURNER PENELOPE (GB)
MARAMAI SAMUELE (GB)
REUILLON TRISTAN (GB)
KHOO JA HEOUK (KR)
CHOI SOONGYU (KR)
PARK YOUNG WHAN (KR)
WARD SIMON (GB)
LE GRAND DARREN (GB)
WEST RYAN (GB)
TURNER PENELOPE (GB)
MARAMAI SAMUELE (GB)
REUILLON TRISTAN (GB)
Application Number:
PCT/KR2022/008105
Publication Date:
December 15, 2022
Filing Date:
June 09, 2022
Export Citation:
Assignee:
AVELOS THERAPEUTICS INC (KR)
International Classes:
C07D401/14; A61K31/53; A61K31/5377; A61P35/00; C07D403/04; C07D403/14; C07D405/14; C07D417/14; C07D471/04; C07D513/04
Domestic Patent References:
| WO2014084778A1 | 2014-06-05 |
Foreign References:
| US20110275611A1 | 2011-11-10 |
Other References:
MEDINA J R, BECKER C J, BLACKLEDGE C W, DUQUENNE C, FENG Y, GRANT S W, HEERDING D, LI W H, MILLER W H, ROMERIL S P, SCHERZER D, SH: "Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 54, no. 6, 24 March 2011 (2011-03-24), US , pages 1871 - 1895, XP002736564, ISSN: 0022-2623, DOI: 10.1021/jm101527u
KOTASTHANE ANUJA, MULAKALA CHANDRIKA, VISWANADHAN VELLARKAD N.: "Applying conformational selection theory to improve crossdocking efficiency in 3-phosphoinositide dependent protein kinase-1 : Conformational Selection and Crossdocking", PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS, JOHN WILEY & SONS, INC., US, vol. 82, no. 3, 1 January 2014 (2014-01-01), US , pages 436 - 451, XP009541853, ISSN: 0887-3585, DOI: 10.1002/prot.24410
KLUG DANA M., TSCHIEGG LAURA, DIAZ ROSARIO, ROJAS-BARROS DOMINGO, PEREZ-MORENO GUIOMAR, CEBALLOS GLORIA, GARCÍA-HERNÁNDEZ RAQUEL, : "Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 5, 1 March 2012 (2012-03-01), US , pages 2527 - 2546, XP009541854, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01506
KOTASTHANE ANUJA, MULAKALA CHANDRIKA, VISWANADHAN VELLARKAD N.: "Applying conformational selection theory to improve crossdocking efficiency in 3-phosphoinositide dependent protein kinase-1 : Conformational Selection and Crossdocking", PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS, JOHN WILEY & SONS, INC., US, vol. 82, no. 3, 1 January 2014 (2014-01-01), US , pages 436 - 451, XP009541853, ISSN: 0887-3585, DOI: 10.1002/prot.24410
KLUG DANA M., TSCHIEGG LAURA, DIAZ ROSARIO, ROJAS-BARROS DOMINGO, PEREZ-MORENO GUIOMAR, CEBALLOS GLORIA, GARCÍA-HERNÁNDEZ RAQUEL, : "Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 5, 1 March 2012 (2012-03-01), US , pages 2527 - 2546, XP009541854, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01506
Attorney, Agent or Firm:
GURU IP LAW FIRM (KR)
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