PREPARATION OF SUBSTITUTED QUINAZOLINES

Title:

PREPARATION OF SUBSTITUTED QUINAZOLINES

Document Type and Number:

WIPO Patent Application WO2004069791

Kind Code:

A3

Abstract:

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, retenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.

Inventors:

BARTH HUBERT GANGOLF KLEMENS (DE)
BRIDGES ALEXANDER JAMES (US)
HEEMSTRA RONALD JOSEPH (US)
HORNE NICOLE MARCIA (US)
HUGHES ROBERT CRAIG (US)
JACKS THOMAS ELLIOTT (US)
MCNAMARA DENNIS JOSEPH (US)
SCHNEIDER SIMON (DE)
STEINER KLAUS IRENAEUS (DE)
TOOGOOD PETER LAURENCE (US)
WINTERS ROY THOMAS (US)

Application Number:

PCT/IB2004/000321

Publication Date:

December 16, 2004

Filing Date:

February 03, 2004

Export Citation:

Click for automatic bibliography generation Help

Assignee:

WARNER LAMBERT CO (US)
BARTH HUBERT GANGOLF KLEMENS (DE)
BRIDGES ALEXANDER JAMES (US)
HEEMSTRA RONALD JOSEPH (US)
HORNE NICOLE MARCIA (US)
HUGHES ROBERT CRAIG (US)
JACKS THOMAS ELLIOTT (US)
MCNAMARA DENNIS JOSEPH (US)
SCHNEIDER SIMON (DE)
STEINER KLAUS IRENAEUS (DE)
TOOGOOD PETER LAURENCE (US)
WINTERS ROY THOMAS (US)

International Classes:

C07D239/94; (IPC1-7): C07D239/94

Domestic Patent References:

WO1997038983A1	1997-10-23
WO2002050043A1	2002-06-27
WO2001062743A2	2001-08-30

Download PDF:

View/Download PDF PDF Help

Previous Patent: CRYSTALLINE MODIFICATIONS OF TRIAZINYLAMINOSTILBENES

Next Patent: QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR