Title:
PREPARATION AND USE OF ALKYLATING AGENTS
Document Type and Number:
WIPO Patent Application WO2005009928
Kind Code:
A3
Abstract:
The present disclosure provides methods of synthesizing alkylating agents and methods of use.
Inventors:
LIM JOHN L (US)
Application Number:
PCT/US2004/024316
Publication Date:
April 14, 2005
Filing Date:
July 26, 2004
Export Citation:
Assignee:
QUEENS MEDICAL CT (US)
LIM JOHN L (US)
LIM JOHN L (US)
International Classes:
C07C67/10; C07C213/08; C07C227/16; C07C269/06; C07C319/14; C07D213/20; C07D453/02; C07C215/40; C07C229/36; C07C271/34; C07C323/03; C07C323/58; (IPC1-7): C07C213/08; C07C227/16; C07C269/06; C07D453/02
Domestic Patent References:
| WO2001082864A2 | 2001-11-08 |
Other References:
HARA, T. ET AL.: "Developement of 18F-Fluorethylcholine for Cancer Imaging with PET: Synthesis, Biochemistry and Prostate Cancer Imaging", J. NUCL. MED., vol. 43, 2002, pages 187 - 199, XP002313434
IWATA, R. ET AL.: "Radiosynthesis of O-[11C]methyl-L-tyrosine and O-[18F]Fluoromethyl-L-tyrosine as potential PET tracers for imaging amino acid transport", J. LABEL COMPD. RADIOPHARM, vol. 46, May 2003 (2003-05-01), pages 555 - 566, XP002313435
ZHANG M-R ET AL: "Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor", APPLIED RADIATION AND ISOTOPES, PERGAMON PRESS LTD., EXETER, GB, vol. 57, no. 3, September 2002 (2002-09-01), pages 335 - 342, XP004370242, ISSN: 0969-8043
ZHANG, M-R ET AL.: "N-[18F]fluoroethyl-4-piperidyl Acetate ([18F]FEtP4A): A PET Tracer for Imaging Brain Acetylchlolinesterase In Vivo", BIOORG. MED. CHEM., vol. 11, 12 June 2003 (2003-06-12), pages 2519 - 27, XP002313436
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BLOCK, DIRK: "Applied carrier-free 18F-fluoroalkylation and 18F-fluoroacylation", XP002313439, retrieved from STN Database accession no. 1988:204176
KIESEWETTER D. O. ET AL: "RADIOCHEMICAL SYNTHESIS OF [18F]FLUORORACLOPRIDE", INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART A: APPLIED RADIATION AND ISOTOPES, PERGAMON PRESS LTD., EXETER, GB, vol. 40, no. 6, January 1989 (1989-01-01), pages 455 - 460, XP000037425
ZHANG, J. ET AL.: "Synthesis and Evaluation of Two Positron-Labeled Nitric Oxide Synthase Inhibitors, S-[11C]Methylisothiourea and S-(2-[18F]Fluoroethyl)isothiourea, as Potential Positron Emission Tomography Tracers", J. MED. CHEM., vol. 39, no. 26, 1996, pages 5110 - 5118, XP002313437
CHESIS P. L. ET AL.: "N-(3-[18F]Fluoropropyl)-N-nordiprenorphine: Synthesis and Characterization of a New Agent for Imaging Opioid Receptors with Positron Emission Tomography", J. MED. CHEM., vol. 33, no. 5, 1990, pages 1482 - 90, XP002313438
HAMACHER K. ET AL: "EFFICIENT STEREOSPECIFIC SYNTHESIS OF NO-CARRIER-ADDED 2-[18F]- FLUORO-2-DEOXY-D-GLUCOSE USING AMINOPOLYETHER SUPPORTED NUCLEOPHILIC SUBSTITUTION", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE. NEW YORK, US, vol. 27, no. 2, 1 February 1986 (1986-02-01), pages 235 - 238, XP000675995, ISSN: 0161-5505
LIM, J. L. ET AL.: "AUTOMATED PRODUCTION OF [18F]FECH AND [18f]FCH: PREPARATION AND USE OF [18F]FLUOROALKANE SULFONATES AS FLUOROALKYLATION AGENTS", J. LABEL COMPD. RADIOPHARM., vol. 46, August 2003 (2003-08-01), pages S46, XP002313484
See also references of EP 1660433A2
IWATA, R. ET AL.: "Radiosynthesis of O-[11C]methyl-L-tyrosine and O-[18F]Fluoromethyl-L-tyrosine as potential PET tracers for imaging amino acid transport", J. LABEL COMPD. RADIOPHARM, vol. 46, May 2003 (2003-05-01), pages 555 - 566, XP002313435
ZHANG M-R ET AL: "Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor", APPLIED RADIATION AND ISOTOPES, PERGAMON PRESS LTD., EXETER, GB, vol. 57, no. 3, September 2002 (2002-09-01), pages 335 - 342, XP004370242, ISSN: 0969-8043
ZHANG, M-R ET AL.: "N-[18F]fluoroethyl-4-piperidyl Acetate ([18F]FEtP4A): A PET Tracer for Imaging Brain Acetylchlolinesterase In Vivo", BIOORG. MED. CHEM., vol. 11, 12 June 2003 (2003-06-12), pages 2519 - 27, XP002313436
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BLOCK, DIRK: "Applied carrier-free 18F-fluoroalkylation and 18F-fluoroacylation", XP002313439, retrieved from STN Database accession no. 1988:204176
KIESEWETTER D. O. ET AL: "RADIOCHEMICAL SYNTHESIS OF [18F]FLUORORACLOPRIDE", INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART A: APPLIED RADIATION AND ISOTOPES, PERGAMON PRESS LTD., EXETER, GB, vol. 40, no. 6, January 1989 (1989-01-01), pages 455 - 460, XP000037425
ZHANG, J. ET AL.: "Synthesis and Evaluation of Two Positron-Labeled Nitric Oxide Synthase Inhibitors, S-[11C]Methylisothiourea and S-(2-[18F]Fluoroethyl)isothiourea, as Potential Positron Emission Tomography Tracers", J. MED. CHEM., vol. 39, no. 26, 1996, pages 5110 - 5118, XP002313437
CHESIS P. L. ET AL.: "N-(3-[18F]Fluoropropyl)-N-nordiprenorphine: Synthesis and Characterization of a New Agent for Imaging Opioid Receptors with Positron Emission Tomography", J. MED. CHEM., vol. 33, no. 5, 1990, pages 1482 - 90, XP002313438
HAMACHER K. ET AL: "EFFICIENT STEREOSPECIFIC SYNTHESIS OF NO-CARRIER-ADDED 2-[18F]- FLUORO-2-DEOXY-D-GLUCOSE USING AMINOPOLYETHER SUPPORTED NUCLEOPHILIC SUBSTITUTION", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE. NEW YORK, US, vol. 27, no. 2, 1 February 1986 (1986-02-01), pages 235 - 238, XP000675995, ISSN: 0161-5505
LIM, J. L. ET AL.: "AUTOMATED PRODUCTION OF [18F]FECH AND [18f]FCH: PREPARATION AND USE OF [18F]FLUOROALKANE SULFONATES AS FLUOROALKYLATION AGENTS", J. LABEL COMPD. RADIOPHARM., vol. 46, August 2003 (2003-08-01), pages S46, XP002313484
See also references of EP 1660433A2
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