Title:
PREPARATION AND USE OF A BIVALENT VACCINE AGAINST MORPHINE-HEROIN ADDICTION
Document Type and Number:
WIPO Patent Application WO2006004390
Kind Code:
A3
Abstract:
The structural design, preparative methods and chemical composition of two structural formulations of bivalent vaccines against morphine-heroin addiction (morphine-6-hemisuccinyl-EDC-TFCS-tetanic toxoid and 3-0-carboxymethylmorphine-EDC-TFCS-tetanic toxoid), are disclosed. These vaccines are suitable for human use in which they are capable of triggering the synthesis of polyclonal antibodies against morphine opiate and its structural analogue, heroine, through the repeated I vivo administration of these formulations, in active vaccination protocols, in pre-clinical studies in rodents.
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Inventors:
ANTON PALMA BENITO (MX)
LEFF GELMAN PHILIPPE (MX)
LEFF GELMAN PHILIPPE (MX)
Application Number:
PCT/MX2005/000049
Publication Date:
September 21, 2006
Filing Date:
July 05, 2005
Export Citation:
Assignee:
TE MUNIZ INST NAC DE PSIQUIATR (MX)
ANTON PALMA BENITO (MX)
LEFF GELMAN PHILIPPE (MX)
ANTON PALMA BENITO (MX)
LEFF GELMAN PHILIPPE (MX)
International Classes:
A61K47/48
Domestic Patent References:
| WO1992003163A1 | 1992-03-05 | |||
| WO1998014216A2 | 1998-04-09 | |||
| WO1996030049A2 | 1996-10-03 | |||
| WO2004076677A2 | 2004-09-10 |
Foreign References:
| CN1196955A | 1998-10-28 |
Other References:
GEBHART G. F.: "Morphine-6-hemisuccinate as a narcotic analgesic", LIFE SCIENCE, vol. 18, 1976, pages 829 - 836, XP008062987
AKBARZADEH A. ET AL: "Design and synthesis of a morphine-6-succinyl-bovine serum albumin hapten for vaccine development", BIOTECHNOL. APPL. BIOCHEM., vol. 30, 1999, pages 139 - 145, XP008062993
"MORPHINE-3-SUCCINYL-BOVINE SERUM ALBUMIN: AN IMMUNOGENIC HAPTEN-PROTEIN CONJUGATE", SCIENCE, vol. 176, 1972, pages 1143 - 1145, XP008063062
ANONYMOUS: "TFCS 22299: TFCS, N-(e-Trifluoroacetylcaproyloxy)succinimide ester", INTERNET ARTICLE, XP002386871, Retrieved from the Internet
CARRERA R. A.: "A second-generation vaccine protects against the psychoactive effects of cocaine", PNAS, vol. 98, February 2001 (2001-02-01), pages 1988 - 1992, XP008063031
HEADING C. E.: "TA-CD Xenova", IDRUGS, vol. 5, 2002, pages 1070 - 1074, XP008062988
AKBARZADEH A. ET AL: "Design and synthesis of a morphine-6-succinyl-bovine serum albumin hapten for vaccine development", BIOTECHNOL. APPL. BIOCHEM., vol. 30, 1999, pages 139 - 145, XP008062993
"MORPHINE-3-SUCCINYL-BOVINE SERUM ALBUMIN: AN IMMUNOGENIC HAPTEN-PROTEIN CONJUGATE", SCIENCE, vol. 176, 1972, pages 1143 - 1145, XP008063062
ANONYMOUS: "TFCS 22299: TFCS, N-(e-Trifluoroacetylcaproyloxy)succinimide ester", INTERNET ARTICLE, XP002386871, Retrieved from the Internet
CARRERA R. A.: "A second-generation vaccine protects against the psychoactive effects of cocaine", PNAS, vol. 98, February 2001 (2001-02-01), pages 1988 - 1992, XP008063031
HEADING C. E.: "TA-CD Xenova", IDRUGS, vol. 5, 2002, pages 1070 - 1074, XP008062988
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