Title:
THE PREPARATION AND USE OF A CURCUMIN-ZINC COMPOUND AND ITS SOLID DISPERSION
Document Type and Number:
WIPO Patent Application WO/2009/079902
Kind Code:
A1
Abstract:
A curcumin-zinc compound and its solid dispersion are prepared. The uses of the curcumin-zinc compound and its solid dispersion are also described. Curcumin and zinc acetate were respectively dissolved in an organic solvent. The solution of zinc acetate was dropwise added to the solution of curcumin under nitrogen. The mixture was stirred and refluxed, then cooled and filtered. The precipitate was collected and washed, then dried under vacuum to give the curcumin-zinc compound. The curcumin-zinc compound and polyvinylpyrrolidone are dissolved in anhydrous alcohol in a mass ratio of 1:1~1:28 under nitrogen. The mixture was homogenized and filtered. The filtrate was processed by spray drying to give the solid dispersion of the curcumin-zinc compound.
Inventors:
MEI XUETING (CN)
XU DONGHUI (CN)
XU SHIBO (CN)
XU DONGHUI (CN)
XU SHIBO (CN)
Application Number:
PCT/CN2008/001086
Publication Date:
July 02, 2009
Filing Date:
June 04, 2008
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
MEI XUETING (CN)
XU DONGHUI (CN)
XU SHIBO (CN)
MEI XUETING (CN)
XU DONGHUI (CN)
XU SHIBO (CN)
International Classes:
A61K9/00; C07F3/06; A61K31/122; A61K31/315; A61P1/04; A61P3/06; A61P9/00; A61P25/28; A61P29/00; A61P37/00; C07C49/213; C07C49/215; C07C49/245
Foreign References:
| CN1709228A | 2005-12-21 |
Other References:
BAUM L ET AL.: "Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models", JOURNAL OF ALZHEIMER'S DISEASE, vol. 6, no. 4, 2004, pages 367 - 377, XP008135315
Attorney, Agent or Firm:
GUANGZHOU YUEGAO PATENT AGENT LIMITED CORPORATION (10/F Block D Bihaiwang,No. 37 Linjing Road,The Pearlriver New City CBD,Guangzhou, Guangdong 3, CN)
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