Title:
PREPARATION WITH IMPROVED BIOABSORBABILITY OF SAPROPTERIN HYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO/2007/072911
Kind Code:
A1
Abstract:
It is intended to provide a method for significantly improving the bioavailability of
orally administered sapropterin hydrochloride which is used as a therapeutic agent
for BH4 responsive hyperphenylalaninemia and a preparation for oral administration or
a preparation for oral intake with improved bioavailability. It is a preparation in
which the bioavailability of sapropterin hydrochloride has been improved characterized
by containing sapropterin hydrochloride and an absorption promoter comprising
an organic carboxylic acid having a plurality of carboxyl groups in its molecule,
wherein the organic carboxylic acid containing a plurality of carboxyl groups
in its molecule is selected from tartaric acid, citric acid, malic acid, or an
optically active substance, a racemic compound, an anhydride or a hydrate thereof
or a mixture thereof and the addition amount thereof is 0.1 to 100 times the weight
of sapropterin hydrochloride.
Inventors:
OKITSU MITSUHITO (JP)
OGAT ATSUTO (JP)
TANI YOSHIHIRO (JP)
OGAT ATSUTO (JP)
TANI YOSHIHIRO (JP)
Application Number:
PCT/JP2006/325504
Publication Date:
June 28, 2007
Filing Date:
December 21, 2006
Export Citation:
Assignee:
ASUBIO PHARMA CO LTD (JP)
OKITSU MITSUHITO (JP)
OGAT ATSUTO (JP)
TANI YOSHIHIRO (JP)
OKITSU MITSUHITO (JP)
OGAT ATSUTO (JP)
TANI YOSHIHIRO (JP)
International Classes:
A61K31/519; A61K9/16; A61K9/20; A61K9/48; A61K47/12; A61P7/00; A61P13/02
Domestic Patent References:
| WO2004017955A1 | 2004-03-04 |
Foreign References:
| JPH07188232A | 1995-07-25 | |||
| JPH06192100A | 1994-07-12 | |||
| JP2005015417A | 2005-01-20 | |||
| JPS57146723A | 1982-09-10 | |||
| JP2004528345A | 2004-09-16 |
Other References:
See also references of EP 1964566A4
Attorney, Agent or Firm:
KUSAMA, Osamu (7F Iwata Bldg., 5-12, Iidabashi 4-chom, Chiyoda-ku Tokyo 72, JP)
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