Title:
PRESERVATIVE COMPOSITION FOR BIOLOGICAL SAMPLES
Document Type and Number:
WIPO Patent Application WO/2023/243727
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a preservative composition which is used in place of or in combination with a cell-penetrating substance such as DMSO that has been commonly used in a culture medium for cryopreservation use and a liquid for cryopreservation use to reduce the toxicity of the cell-penetrating substance and improve the cryopreservation effect of the cell-penetrating substance. Provided are: a zwitterionic polymer represented by general formula (1), or a labelled product of the zwitterionic polymer; and a preservative composition for biological samples, which contains the zwitterionic polymer or the labelled product. (In the formula, X1 and X2 may be the same as or different from each other, and each independently represent a carbon atom or a nitrogen atom; Y1 and Y2 may be the same as or different from each other, and each independently represent an anion selected from -COO-, -SO3 -, -OP=O(H)O-, -OP=O(CH3)O- and -OP=O(OR1)O-; Z represents a hydrogen atom, an aromatic hydrocarbon group having 6 to 10 carbon atoms in which an alkyl group may be substituted, a 5- to 6-membered aromatic heterocyclic group in which an alkyl group may be substituted, a nitrogenated heterocyclic ammonium salt in which an alkyl group may be substituted, a tetraalkyl ammonium salt, a tetraphenyl phosphonium salt, a tetraalkyl phosphonium salt, a trialkyl sulfonium salt, or a linear or branched alkyl group having 1 to 22 carbon atoms which may have 1 to 3 oxygen atoms in a molecular chain thereof; e and f each independently represent an integer of 0 or 1; l, m and n are numerical values respectively representing the content ratios of repeating units corresponding thereto and respectively satisfying the formulae 0 < l ≤ 1, 0 ≤ m < 1, 0 ≤ n < 1 and l+m+n = 1; and p, q, r, s and t each independently represent an integer of 0 to 6.)
Inventors:
KURODA KOSUKE (JP)
HIRATA EISHU (JP)
TANAKA DAISUKE (JP)
HIRATA EISHU (JP)
TANAKA DAISUKE (JP)
Application Number:
PCT/JP2023/022488
Publication Date:
December 21, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
International Classes:
C08F26/06; A01N1/02; C08F226/06; C08K3/01; C08K5/053; C08L5/00; C08L39/00; C08L39/04; C12N1/04; C12N5/00
Domestic Patent References:
| WO2021131479A1 | 2021-07-01 |
Foreign References:
| JP2022008203A | 2022-01-13 | |||
| JP2020019878A | 2020-02-06 | |||
| JP2022095009A | 2022-06-28 |
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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