Title:
PREVENTION OF METASTASIS WITH 5-AZA-2'-DEOXYCYTIDINE
Document Type and Number:
WIPO Patent Application WO2000005419
Kind Code:
A9
Abstract:
Tumor metastases are often caused by the elimination of the tumor suppressive effect of DAP-kinase. If the lack of DAP-kinase activity is due to methylation of the DAP-kinase gene, then the tumor suppressive activity of DAP-kinase can be restored by treating with a demethylating agent such as 5-aza-2'-deoxycytidine. Thus, tumor cells of a patient are screened to determine whether DAP-kinase protein is produced by the cells and, if not, to determine if the cells contain DAP-kinase genes which are methylated. If the latter case is so, then the patient is treated with a demethylating agent such as 5-aza-2'-deoxycytidine. If the cells produce DAP-kinase protein, the patient may be prophylactically treated with a demethylating agent or a DNA methyltransferase inhibitor, such as 5-aza-2'-deoxycytidine, in order to prevent eventual loss of DAP-kinase by methylation of the gene and therefore prevent eventual metastasis.
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Inventors:
KIMCHI ADI
Application Number:
PCT/US1999/016836
Publication Date:
June 08, 2000
Filing Date:
July 26, 1999
Export Citation:
Assignee:
YEDA RES & DEV (IL)
MCINNIS PATRICIA A (US)
MCINNIS PATRICIA A (US)
International Classes:
C12Q1/68; C12Q1/6886; (IPC1-7): C12Q1/68
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