Title:
PREVENTION OR TREATMENT AGENT FOR HEPATIC FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2014/092154
Kind Code:
A1
Abstract:
In the present invention, a CBP/β-catenin inhibitor exhibits a superior defibrinating effect with respect to Cre/loxP/HCV-MxCre transgenic mice, which are an experimental animal model for hepatic fibrosis, and is useful as a prevention or treatment drug for hepatic fibrosis.
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Inventors:
ODAGAMI TAKENAO (JP)
KOUJI HIROYUKI (JP)
KOHARA MICHINORI (JP)
KOUJI HIROYUKI (JP)
KOHARA MICHINORI (JP)
Application Number:
PCT/JP2013/083339
Publication Date:
June 19, 2014
Filing Date:
December 12, 2013
Export Citation:
Assignee:
PRISM PHARMA CO LTD (JP)
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
International Classes:
A61K45/00; A61K31/5365; A61P1/16; A61P31/14
Domestic Patent References:
| WO2009148192A1 | 2009-12-10 | |||
| WO2003031448A1 | 2003-04-17 | |||
| WO2004093828A2 | 2004-11-04 | |||
| WO2005116032A2 | 2005-12-08 | |||
| WO2010044485A1 | 2010-04-22 | |||
| WO2010128685A1 | 2010-11-11 | |||
| WO2012115286A1 | 2012-08-30 |
Foreign References:
| JP2008533155A | 2008-08-21 | |||
| JP2011522037A | 2011-07-28 | |||
| JP2009256226A | 2009-11-05 | |||
| JP2009242374A | 2009-10-22 |
Other References:
JASON H. CHENG ET AL.: "Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis", AM J PHYSIOL GASTROINTEST LIVER PHYSIOL, vol. 294, 2008, pages G39 - G49, XP009098423
See also references of EP 2932977A4
MARCH, JERRY: "Advanced Organic Chemistry, 4th edition,", 1992, JOHN WILEY & SONS
HE ET AL., SCIENCE, vol. 281, 1998, pages 1509 - 1512
KOLLIGS ET AL., MOL. CELL. BIOL., vol. 19, 1999, pages 5696 - 5706
CRAWFORD ET AL., ONCOGENE, vol. 18, 1999, pages 2883 - 2891
SHTUTMAN ET AL., PROC. NATL. ACAD. SCI. USA., vol. 11, 1999, pages 5522 - 5527
TETSU; MCCORMICK, NATURE, vol. 398, 1999, pages 422 - 426
KEN-ICHI TAKEMARU; RANDALL T. MOON, J. CELL. BIOL., vol. 149, no. 2, 2000, pages 249 - 254
PROC. NATL. ACAD. SCI. USA, vol. 90, pages 6037 - 6041
See also references of EP 2932977A4
MARCH, JERRY: "Advanced Organic Chemistry, 4th edition,", 1992, JOHN WILEY & SONS
HE ET AL., SCIENCE, vol. 281, 1998, pages 1509 - 1512
KOLLIGS ET AL., MOL. CELL. BIOL., vol. 19, 1999, pages 5696 - 5706
CRAWFORD ET AL., ONCOGENE, vol. 18, 1999, pages 2883 - 2891
SHTUTMAN ET AL., PROC. NATL. ACAD. SCI. USA., vol. 11, 1999, pages 5522 - 5527
TETSU; MCCORMICK, NATURE, vol. 398, 1999, pages 422 - 426
KEN-ICHI TAKEMARU; RANDALL T. MOON, J. CELL. BIOL., vol. 149, no. 2, 2000, pages 249 - 254
PROC. NATL. ACAD. SCI. USA, vol. 90, pages 6037 - 6041
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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