Title:
PREVENTION OR TREATMENT OF FIBROTIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2020/171206
Kind Code:
A1
Abstract:
This invention provides technology for identifying the marker protein of myofibroblasts and preventing or treating fibrotic disease. This invention relates to a preventive or therapeutic drug for fibrotic disease, which contains a GPR176 inhibitor as an active ingredient.
Inventors:
NAKAYA MICHIO (JP)
KUROSE HITOSHI (JP)
KUROSE HITOSHI (JP)
Application Number:
PCT/JP2020/007072
Publication Date:
August 27, 2020
Filing Date:
February 21, 2020
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61K39/395; A61K31/7088; A61K31/7105; A61K31/711; A61K31/713; A61K45/00; A61K48/00; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P43/00
Domestic Patent References:
| WO2004024763A1 | 2004-03-25 |
Foreign References:
| JP2004081122A | 2004-03-18 |
Other References:
HATA S. ET AL.: "cDNA cloning of a putative G protein-coupled receptor from brain", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1261, no. 1, 1995, pages 121 - 125, XP000914574, ISSN: 0006-3002
NAKAGAWA, SHUNPEI: "G-protein-coupled receptor signaling regulating the center of the circadian clock", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 267, no. 6, 10 November 2018 (2018-11-10), pages 429 - 433, XP009530872
DOI MASAO AND MURAI IORI, KUNISUE SUMIHIRO, SETSU GENZUI, UCHIO NAOHIRO, TANAKA RINA, KOBAYASHI SAKURAKO, SHIMATANI HIROYUKI, HAYA: "Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour", NATURE COMMUNICATIONS, vol. 7, no. 10583, 17 February 2016 (2016-02-17), pages 1 - 13, XP055733058, ISSN: 2041-1723, DOI: 10.1038/ncomms10583
IMANAKA, KYOKO; HIROE, MICHIAKI: "Cardiac Fibrosis: the role of myocardial interstitium", HEART VIEW, vol. 21, no. 9, 2017, pages 55 (939) - 61 (945), XP009530870, ISSN: 1342-6591
NATURE COMMUNICATIONS, vol. 7, 17 February 2016 (2016-02-17), pages 10583
SCIENCE, vol. 239, 1988, pages 1412 - 1416
METHODS IN ENZYMOL., vol. 180, 1989, pages 262
ANN. REV. BIOPHYS. BIOPHYS. CHEM., vol. 17, 1988, pages 167
NUCLEIC ACID RES., vol. 25, 1997, pages 5010
NATURE BIOTECH, vol. 15, 1997, pages 537
NUCLEIC ACID RES., vol. 27, 1999, pages 2387
BIOCHEMISTRY, vol. 31, 1992, pages 12055
MORIMOTO ET AL., J. BIOCHEM. BIOPHYS. MEHTODS, vol. 24, 1992, pages 107 - 17
BRENNAN ET AL., SCIENCE, vol. 229, 1985, pages 81
CO ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 76
PLUCKTHUNSKERRA, METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
ROUSSEAUX ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 63
BIRDWALKER, TRENDS BIOTECHNOL, vol. 9, 1991, pages 132 - 7
PLUCKTHUN: "The Pharmacology of Monoclonal Antibody", vol. 113, 1994, SPRINGER VERLAG, pages: 269 - 315
MOL. CELL. BIOL., vol. 1, 1981, pages 854 - 864
NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
CELL, vol. 23, 1981, pages 175 - 182
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216 - 4220
FOSTER ET AL., CELL, vol. 179, no. 89, 2019, pages 5 - 908
J. BIOCHEM., vol. 120, 1996, pages 1232 - 1238
WANG, F. ET AL., J. MOL. DIAGNOSTICS, vol. 14, 2012, pages 22 - 29
DAVIS, J.MOLKENTIN, J. D., J. MOL. CELL. CARDIOL., vol. 70, 2014, pages 9 - 18
LIEHN, E. A.POSTEA, 0.CURAJ, A.MARX, N., J. AM. COLL. CARDIOL., vol. 58, 2011, pages 2357 - 2362
TAKEDA, N. ET AL., J. CLIN. INVEST., vol. 120, 2010, pages 254 - 265
KANISICAK, 0. ET AL., NAT. COMMUN., vol. 7, 2016, pages 1 - 14
OKA, T. ET AL., CIRC. RES., vol. 101, 2007, pages 313 - 321
CARRINGTON, R. JORDANS. PITCHFORD, S.C.PAGE, C.P., PULM. PHARMACOL. THERAUPTICS, vol. 51, 2018, pages 73 - 78
HUMPHREYS, B.D., MECHANISMS OF RENAL FIBROSIS, 2018, Retrieved from the Internet
MARTINEZ-KLIMOVA, E.APARICIO-TREJO, 0. E.TAPIA, E.PEDRAZA-CHAVERRI, J., BIOMOLECULES, vol. 9, 2019
TAKEDA, N.MANABE, I., INT. J. INFLAM., vol. 2011, 2011, pages 1 - 13
SWONGER, J.M.LIU, J.S.IVEY, M.J.TALLQUIST, M. D., DIFFERENTIATION, vol. 92, 2016, pages 66 - 83
See also references of EP 3928791A4
NAKAGAWA, SHUNPEI: "G-protein-coupled receptor signaling regulating the center of the circadian clock", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 267, no. 6, 10 November 2018 (2018-11-10), pages 429 - 433, XP009530872
DOI MASAO AND MURAI IORI, KUNISUE SUMIHIRO, SETSU GENZUI, UCHIO NAOHIRO, TANAKA RINA, KOBAYASHI SAKURAKO, SHIMATANI HIROYUKI, HAYA: "Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour", NATURE COMMUNICATIONS, vol. 7, no. 10583, 17 February 2016 (2016-02-17), pages 1 - 13, XP055733058, ISSN: 2041-1723, DOI: 10.1038/ncomms10583
IMANAKA, KYOKO; HIROE, MICHIAKI: "Cardiac Fibrosis: the role of myocardial interstitium", HEART VIEW, vol. 21, no. 9, 2017, pages 55 (939) - 61 (945), XP009530870, ISSN: 1342-6591
NATURE COMMUNICATIONS, vol. 7, 17 February 2016 (2016-02-17), pages 10583
SCIENCE, vol. 239, 1988, pages 1412 - 1416
METHODS IN ENZYMOL., vol. 180, 1989, pages 262
ANN. REV. BIOPHYS. BIOPHYS. CHEM., vol. 17, 1988, pages 167
NUCLEIC ACID RES., vol. 25, 1997, pages 5010
NATURE BIOTECH, vol. 15, 1997, pages 537
NUCLEIC ACID RES., vol. 27, 1999, pages 2387
BIOCHEMISTRY, vol. 31, 1992, pages 12055
MORIMOTO ET AL., J. BIOCHEM. BIOPHYS. MEHTODS, vol. 24, 1992, pages 107 - 17
BRENNAN ET AL., SCIENCE, vol. 229, 1985, pages 81
CO ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 76
PLUCKTHUNSKERRA, METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
ROUSSEAUX ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 63
BIRDWALKER, TRENDS BIOTECHNOL, vol. 9, 1991, pages 132 - 7
PLUCKTHUN: "The Pharmacology of Monoclonal Antibody", vol. 113, 1994, SPRINGER VERLAG, pages: 269 - 315
MOL. CELL. BIOL., vol. 1, 1981, pages 854 - 864
NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
CELL, vol. 23, 1981, pages 175 - 182
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216 - 4220
FOSTER ET AL., CELL, vol. 179, no. 89, 2019, pages 5 - 908
J. BIOCHEM., vol. 120, 1996, pages 1232 - 1238
WANG, F. ET AL., J. MOL. DIAGNOSTICS, vol. 14, 2012, pages 22 - 29
DAVIS, J.MOLKENTIN, J. D., J. MOL. CELL. CARDIOL., vol. 70, 2014, pages 9 - 18
LIEHN, E. A.POSTEA, 0.CURAJ, A.MARX, N., J. AM. COLL. CARDIOL., vol. 58, 2011, pages 2357 - 2362
TAKEDA, N. ET AL., J. CLIN. INVEST., vol. 120, 2010, pages 254 - 265
KANISICAK, 0. ET AL., NAT. COMMUN., vol. 7, 2016, pages 1 - 14
OKA, T. ET AL., CIRC. RES., vol. 101, 2007, pages 313 - 321
CARRINGTON, R. JORDANS. PITCHFORD, S.C.PAGE, C.P., PULM. PHARMACOL. THERAUPTICS, vol. 51, 2018, pages 73 - 78
HUMPHREYS, B.D., MECHANISMS OF RENAL FIBROSIS, 2018, Retrieved from the Internet
MARTINEZ-KLIMOVA, E.APARICIO-TREJO, 0. E.TAPIA, E.PEDRAZA-CHAVERRI, J., BIOMOLECULES, vol. 9, 2019
TAKEDA, N.MANABE, I., INT. J. INFLAM., vol. 2011, 2011, pages 1 - 13
SWONGER, J.M.LIU, J.S.IVEY, M.J.TALLQUIST, M. D., DIFFERENTIATION, vol. 92, 2016, pages 66 - 83
See also references of EP 3928791A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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