Title:
PREVENTIVE AGENT, DISEASE PROGRESSION INHIBITOR, OR THERAPEUTIC AGENT FOR CENTRAL DEMYELINATING DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/228701
Kind Code:
A1
Abstract:
The present invention provides a preventive agent, disease progression inhibitor, or therapeutic agent for central demyelinating diseases, comprising a FFAR1 receptor agonist.
Inventors:
IKEDA RIEKO (JP)
Application Number:
PCT/JP2023/017205
Publication Date:
November 30, 2023
Filing Date:
May 02, 2023
Export Citation:
Assignee:
NAT CENTER NEUROLOGY & PSYCHIATRY (JP)
International Classes:
A61K45/00; A61K31/201; A61P21/00; A61P25/28; C07K14/705; C12N15/12
Foreign References:
| KR20210054741A | 2021-05-14 |
Other References:
NAM SUNG MIN, CHOI JONG HEE, CHOI SUN-HYE, CHO HEE-JUNG, CHO YEON-JIN, RHIM HYEWHON, KIM HYOUNG-CHUN, CHO IK-HYUN, KIM DO-GEUN, NA: "Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor", JOURNAL OF GINSENG RESEARCH, GO'RYEO INSAM HAGHOE, SEOUL,, KR, vol. 45, no. 3, 1 May 2021 (2021-05-01), KR , pages 390 - 400, XP093112386, ISSN: 1226-8453, DOI: 10.1016/j.jgr.2020.04.002
MIJAN MOHAMMAD AL, KIM JI YOUNG, MOON SO-YOUNG, CHOI SUN-HYE, NAH SEUNG-YEOL, YANG HYUN-JEONG: "Gintonin Enhances Proliferation, Late Stage Differentiation, and Cell Survival From Endoplasmic Reticulum Stress of Oligodendrocyte Lineage Cells", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 10, CH , XP093112391, ISSN: 1663-9812, DOI: 10.3389/fphar.2019.01211
CHO YEON-JIN, CHOI SUN-HYE, LEE RAMI, HWANG HONGIK, RHIM HYEWHON, CHO IK-HYUN, KIM HYOUNG-CHUN, LEE JEONG-IK, HWANG SUNG-HEE, NAH : "Ginseng Gintonin Contains Ligands for GPR40 and GPR55", MOLECULES, MDPI AG, CH, vol. 25, no. 5, CH , pages 1102, XP093112393, ISSN: 1420-3049, DOI: 10.3390/molecules25051102
MARUYAMA TAKASHI, TANABE SHOGO, UYEDA AKIKO, SUZUKI TATSUNORI, MURAMATSU RIEKO: "Free fatty acids support oligodendrocyte survival in a mouse model of amyotrophic lateral sclerosis", FRONTIERS IN CELLULAR NEUROSCIENCE, FRONTIERS RESEARCH FOUNDATION, CH, vol. 17, CH , XP093112402, ISSN: 1662-5102, DOI: 10.3389/fncel.2023.1081190
MIJAN MOHAMMAD AL, KIM JI YOUNG, MOON SO-YOUNG, CHOI SUN-HYE, NAH SEUNG-YEOL, YANG HYUN-JEONG: "Gintonin Enhances Proliferation, Late Stage Differentiation, and Cell Survival From Endoplasmic Reticulum Stress of Oligodendrocyte Lineage Cells", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 10, CH , XP093112391, ISSN: 1663-9812, DOI: 10.3389/fphar.2019.01211
CHO YEON-JIN, CHOI SUN-HYE, LEE RAMI, HWANG HONGIK, RHIM HYEWHON, CHO IK-HYUN, KIM HYOUNG-CHUN, LEE JEONG-IK, HWANG SUNG-HEE, NAH : "Ginseng Gintonin Contains Ligands for GPR40 and GPR55", MOLECULES, MDPI AG, CH, vol. 25, no. 5, CH , pages 1102, XP093112393, ISSN: 1420-3049, DOI: 10.3390/molecules25051102
MARUYAMA TAKASHI, TANABE SHOGO, UYEDA AKIKO, SUZUKI TATSUNORI, MURAMATSU RIEKO: "Free fatty acids support oligodendrocyte survival in a mouse model of amyotrophic lateral sclerosis", FRONTIERS IN CELLULAR NEUROSCIENCE, FRONTIERS RESEARCH FOUNDATION, CH, vol. 17, CH , XP093112402, ISSN: 1662-5102, DOI: 10.3389/fncel.2023.1081190
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF: