PREVENTIVE AND/OR REMEDY FOR HYPERKALEMIA CONTAINING EP4 AGONIST

Title:

PREVENTIVE AND/OR REMEDY FOR HYPERKALEMIA CONTAINING EP4 AGONIST

Document Type and Number:

WIPO Patent Application WO/2006/016695

Kind Code:

A1

Abstract:

A preventive and/or remedy for hyperkalemia and a potassium excretion promoter containing an EP₄ agonist. Because of promoting potassium excretion, an EP₄ agonist is useful as a preventive and/or remedy for hyperkalemia. A selective EP₄ agonist is useful as a preventive and/or remedy for hyperkalemia having no side effect. Furthermore, an EP₄ agonist is useful in ameliorating various symptoms of hyperkalemia (for example, sensation abnormality, error of perception, sense of exhaustion, muscle paralysis, nausea, vomiting, abdominal pain, diarrhea, arrhythmia, atrioventricular block, ventricular fibrillation, atrial fibrillation, asystole, respiratory arrest and/or respiratory distress and so on).

Inventors:

KUWAHARA ATSUKAZU (JP)
SUZUKI YUICHI (JP)
MARUYAMA TAKAYUKI (JP)

Application Number:

PCT/JP2005/014885

Publication Date:

February 16, 2006

Filing Date:

August 09, 2005

Export Citation:

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Assignee:

ONO PHARMACEUTICAL CO (JP)
KUWAHARA ATSUKAZU (JP)
SUZUKI YUICHI (JP)
MARUYAMA TAKAYUKI (JP)

International Classes:

A61K31/5575; A61K45/00; A61K38/28; A61K45/06; A61K47/40; A61P1/10; A61P1/12; A61P3/02; A61P3/10

Domestic Patent References:

WO2000003980A1	2000-01-27
WO2003009872A1	2003-02-06

Foreign References:

JPH03130227A	1991-06-04
JPH10265454A	1998-10-06
JP2000001472A	2000-01-07

Other References:

TANAKA C. ET AL: "New Yakurigaku", 2002, NANKODO CO. LTD., pages: 196, XP002999352
FUKUSHIMA M.: "japanese language edition", 1999, NIKKEI BUSINESS PUBLICATIONS, INC., article "pag. 138-141,1852-1855", XP002999353

Attorney, Agent or Firm:

Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)

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