Title:
PREVENTIVE OR THERAPEUTIC AGENT FOR INFLAMMATORY DISORDERS AND/OR PAIN DISORDERS
Document Type and Number:
WIPO Patent Application WO/2022/168975
Kind Code:
A1
Abstract:
The present invention exhibits strong preventive effects and/or therapeutic effects with regard to inflammatory disorders and/or pain disorders by combining and administering glutathione trisulfide or a pharmaceutically-acceptable salt thereof and a non-steroidal anti-inflammatory drug or a pharmaceutically acceptable salt thereof.
Inventors:
OHSHIMA ETSUO (JP)
Application Number:
PCT/JP2022/004692
Publication Date:
August 11, 2022
Filing Date:
February 07, 2022
Export Citation:
Assignee:
KYOWA PHARMA CHEMICAL CO LTD (JP)
International Classes:
A61K45/00; A61K38/06; A61P29/00; A61P43/00
Domestic Patent References:
| WO2017057768A1 | 2017-04-06 |
Foreign References:
| JP2001524087A | 2001-11-27 | |||
| JP2021500384A | 2021-01-07 |
Other References:
ZHANG TIANLI, TSUTSUKI HIROYASU, ONO KATUSHIKO, AKAIKE TAKAAKI, SAWA TOMOHIRO: "Antioxidative and anti-inflammatory actions of reactive cysteine persulfides", JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION., TOKYO., JP, vol. 68, no. 1, 1 January 2021 (2021-01-01), JP , pages 5 - 8, XP055955646, ISSN: 0912-0009, DOI: 10.3164/jcbn.20-13
CHENG YU-TING, LU CHI-CHENG, YEN GOW-CHIN: "Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa", MOLECULAR NUTRITION & FOOD RESEARCH, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 61, no. 6, 1 June 2017 (2017-06-01), DE , pages 1600659, XP055955647, ISSN: 1613-4125, DOI: 10.1002/mnfr.201600659
TAWARAYAMA HIROSHI, SUZUKI NORIYUKI, INOUE-YANAGIMACHI MAKI, HIMORI NORIKO, TSUDA SATORU, SATO KOTA, IDA TOMOAKI, AKAIKE TAKAAKI, : "Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells", OCULAR IMMUNOLOGY AND INFLAMMATION, AEOLUS PRESS, BUREN, NL, vol. ahead-of-print, no. ahead-of-print, 10 December 2020 (2020-12-10), NL , pages 1 - 12, XP009538578, ISSN: 0927-3948, DOI: 10.1080/09273948.2020.1833224
T. IDA ET AL., PNAS, vol. 111, no. 21, 27 May 2014 (2014-05-27), pages 7606 - 7611
T. AKAIKE ET AL., NATURE COMMUNICATIONS, vol. 8, no. 1, 27 October 2017 (2017-10-27), pages 1177
CHENG YU-TING, LU CHI-CHENG, YEN GOW-CHIN: "Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa", MOLECULAR NUTRITION & FOOD RESEARCH, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 61, no. 6, 1 June 2017 (2017-06-01), DE , pages 1600659, XP055955647, ISSN: 1613-4125, DOI: 10.1002/mnfr.201600659
TAWARAYAMA HIROSHI, SUZUKI NORIYUKI, INOUE-YANAGIMACHI MAKI, HIMORI NORIKO, TSUDA SATORU, SATO KOTA, IDA TOMOAKI, AKAIKE TAKAAKI, : "Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells", OCULAR IMMUNOLOGY AND INFLAMMATION, AEOLUS PRESS, BUREN, NL, vol. ahead-of-print, no. ahead-of-print, 10 December 2020 (2020-12-10), NL , pages 1 - 12, XP009538578, ISSN: 0927-3948, DOI: 10.1080/09273948.2020.1833224
T. IDA ET AL., PNAS, vol. 111, no. 21, 27 May 2014 (2014-05-27), pages 7606 - 7611
T. AKAIKE ET AL., NATURE COMMUNICATIONS, vol. 8, no. 1, 27 October 2017 (2017-10-27), pages 1177
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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