PREVENTIVES OR REMEDIES FOR ALZHEIMER’S DISEASE OR AMYLOID PROTEIN FIBROSIS INHIBITORS CONTAINING NITROGEN−CONTAINING HETEROARYL COMPOUNDS

Title:

PREVENTIVES OR REMEDIES FOR ALZHEIMER’S DISEASE OR AMYLOID PROTEIN FIBROSIS INHIBITORS CONTAINING NITROGEN−CONTAINING HETEROARYL COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/2003/045923

Kind Code:

A1

Abstract:

Preventives or remedies for Alzheimer’s disease or amyloid protein fibrosis inhibitors containing, as the active ingredient, compounds having the following general formula (I) or pharmacologically acceptable salts thereof&semi and nitrogen−containing heteroaryl derivatives having specific substituents, which are useful as preventives or remedies for Alzheimer’s disease or amyloid protein fibrosis inhibitors, or pharmacologically acceptable salts thereof: (I) wherein R¹ and R² represent each H or alkyl&semi Z¹ and Z² represent each H, alkyl, alkoxy, haloalkyl or halogeno&semi Z³ represents alkoxy, SH, alkylthio, NH₂, mono− or dialkylamino, OH or halogeno&semi Z⁴ and Z⁵ represent each H or halogeno&semi and A represents 4,6−pyrimidine−1,3−diyl, 1,3,5−triazine−2,6−diyl, etc.

Inventors:

MEGURO MASAKI (JP)
ODA TOMIICHIRO (JP)
NAKAGAMI YASUHIRO (JP)
MARUMOTO SHINJI (JP)
KOYAMA KAZUO (JP)
KANEKO ISAO (JP)

Application Number:

PCT/JP2002/012265

Publication Date:

June 05, 2003

Filing Date:

November 25, 2002

Export Citation:

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Assignee:

SANKYO CO (JP)
MEGURO MASAKI (JP)
ODA TOMIICHIRO (JP)
NAKAGAMI YASUHIRO (JP)
MARUMOTO SHINJI (JP)
KOYAMA KAZUO (JP)
KANEKO ISAO (JP)

International Classes:

A61K31/50; A61K31/505; A61K31/53; A61P25/28; A61P43/00; C07D237/20; C07D237/22; C07D239/48; C07D239/50; C07D241/20; C07D251/18; C07D251/48; C07D251/52; C07D251/70; (IPC1-7): C07D237/20; C07D239/48; C07D239/50; C07D251/18; C07D251/52; A61K31/50; A61K31/505; A61K31/53; A61P25/28; A61P43/00

Domestic Patent References:

WO2001055093A1

2001-08-02

Other References: