Title:
PRMT5 INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/021957
Kind Code:
A1
Abstract:
The present invention relates to a PRMT5 inhibitor, a preparation method therefor, and a pharmaceutical use thereof. In particular, the present invention relates to a PRMT5 inhibitor having a compound structure shown in formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use thereof as a PRMT5 inhibitor, and a use thereof in treatment and/or prevention of a PRMT5-mediated disease. The definition of each substituent in the compound of formula (I) is the same as that in the description.
Inventors:
DENG HAIBING (CN)
LIU JIAN (CN)
YANG FEI (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
LIU JIAN (CN)
YANG FEI (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
Application Number:
PCT/CN2023/102508
Publication Date:
February 01, 2024
Filing Date:
June 26, 2023
Export Citation:
Assignee:
ABBISKO THERAPEUTICS CO LTD (CN)
International Classes:
C07D471/04; A61K31/4353; A61P35/00
Domestic Patent References:
| WO2022132914A1 | 2022-06-23 | |||
| WO2021163344A1 | 2021-08-19 | |||
| WO2023034786A1 | 2023-03-09 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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