Title:
PRMT5 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/027703
Kind Code:
A1
Abstract:
Provided are a PRMT5 inhibitor, and a preparation method therefor and a use thereof. Specifically disclosed are a compound as shown in formula I, a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, and a use thereof in the preparation of a drug for treating and/or preventing a cancer. The cancer can be an MTAP-related/mediated cancer.
Inventors:
LUO HUIBING (CN)
WANG JIAPO (CN)
WANG JIAPO (CN)
Application Number:
PCT/CN2023/110538
Publication Date:
February 08, 2024
Filing Date:
August 01, 2023
Export Citation:
Assignee:
SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D405/14; A61K31/498; A61K31/50; A61K31/502; A61K31/5025; A61P35/00; C07D401/04; C07D401/14; C07D413/04; C07D413/14; C07D471/04
Domestic Patent References:
| WO2022192745A1 | 2022-09-15 | |||
| WO2023098439A1 | 2023-06-08 | |||
| WO2022216645A1 | 2022-10-13 | |||
| WO2022216648A1 | 2022-10-13 | |||
| WO2022256806A1 | 2022-12-08 | |||
| WO2023125540A1 | 2023-07-06 |
Foreign References:
| CN114728912A | 2022-07-08 |
Other References:
DATABASE Registry CAS; 1 December 2019 (2019-12-01), ANONYMOUS : "Benzonitrile, 3-fluoro-6-hydroxy -2-iodo-", XP093136809, retrieved from STN Database accession no. 2386223-10-3
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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