Title:
PRMT5-MTA INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/207556
Kind Code:
A1
Abstract:
The present invention provides a compound as a PRMT5-MTA inhibitor, which is a compound represented by formula (A) or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate thereof. The present invention further provides a pharmaceutical composition comprising the compound and use thereof in treating a cancer.
Inventors:
LIU BIN (CN)
GAO FENG (CN)
GUO YONGQI (CN)
WU YONGYONG (CN)
JING LIANDONG (CN)
LI ZHIZHONG (CN)
GAO YU (CN)
WU ZHUO (CN)
GAO FENG (CN)
GUO YONGQI (CN)
WU YONGYONG (CN)
JING LIANDONG (CN)
LI ZHIZHONG (CN)
GAO YU (CN)
WU ZHUO (CN)
Application Number:
PCT/CN2023/087001
Publication Date:
November 02, 2023
Filing Date:
April 07, 2023
Export Citation:
Assignee:
SUZHOU PUHE BIOPHARMA CO LTD (CN)
International Classes:
C07D401/12; A61K31/435; A61P35/00; C07D401/14; C07D403/12; C07D417/14
Domestic Patent References:
| WO2021163344A1 | 2021-08-19 | |||
| WO2021004547A1 | 2021-01-14 |
Foreign References:
| JP2000256194A | 2000-09-19 |
Other References:
BOGOLUBSKY ANDREY V., MOROZ YURII S., MYKHAILIUK PAVEL K., PIPKO SERGEY E., ZHEMERA ANTON V., KONOVETS ANZHELIKA I., STEPANIUK OLE: "2,2,2-Trifluoroethyl Chlorooxoacetate—Universal Reagent for One-Pot Parallel Synthesis of N 1 -Aryl- N 2 -alkyl-Substituted Oxamides", ACS COMBINATIONAL SCIENCE, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 10, 12 October 2015 (2015-10-12), US , pages 615 - 622, XP093034800, ISSN: 2156-8952, DOI: 10.1021/acscombsci.5b00091
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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