Title:
PROBE FOR DETECTION/DETERMINATION OF INOSITOL-1,4,5-TRIPHOSPHORIC ACID AND METHOD OF DETECTING/DETERMINING INOSITOL-1,4,5-TRIPHOSPHORIC ACID WITH THE SAME
Document Type and Number:
WIPO Patent Application WO/2005/113792
Kind Code:
A1
Abstract:
A probe for inositol-1,4,5-triphosphoric acid detection/determination. With the probe, where in living cells and when the acid was produced can be found with high accuracy in a noninvasive manner.
Inventors:
UMEZAWA YOSHIO (JP)
SATO MORITOSHI (JP)
SATO MORITOSHI (JP)
Application Number:
PCT/JP2005/009299
Publication Date:
December 01, 2005
Filing Date:
May 17, 2005
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
UMEZAWA YOSHIO (JP)
SATO MORITOSHI (JP)
UMEZAWA YOSHIO (JP)
SATO MORITOSHI (JP)
International Classes:
C07K7/06; C07K7/08; C07K14/705; C12N15/09; C12Q1/02; G01N21/78; G01N33/15; G01N33/50; G01N33/53; G01N33/542; G01N33/566; C07K19/00; (IPC1-7): C12Q1/02; C12N15/09; G01N21/78; G01N33/15; G01N33/50; G01N33/566
Domestic Patent References:
| WO2002003069A1 | 2002-01-10 |
Foreign References:
| JP2004057015A | 2004-02-26 | |||
| JP2002250730A | 2002-09-06 | |||
| JP2005040132A | 2005-02-17 |
Other References:
NEZU A. ET AL.: "Measurement of intracellular IP3 concentration in living cells using the novel ratiometric IP3 biosensor.", JOURNAL OF PHARMACOLOGICAL SCIENCE., vol. 94, 2004, pages 138, XP002991090
YOSHIKAWA F. ET AL.: "Mutational Analysis of the Ligand Binding Site of the Inositol 1,4,5-Triphosphate Receptor.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 30, 1996, pages 1877 - 18284, XP002991091
TANIMURA A. ET AL.: "Fluorescent Biosensor for Quantitative Real-time Measurements of Inositol 1,4,5-Triophosphate in Signal Living Cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 279, no. 37, 10 September 2004 (2004-09-10), pages 38095 - 38098, XP002991314
NEZU ET AL., J PHARMACOLOGICAL SCIENCE, vol. 94, 2004, pages 138
YOSHIKAWA ET AL., J BIOL CHEM, vol. 271, 1996, pages 18277 - 18284
SCIENCE, vol. 284, 1999, pages 1527 - 1530
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 7380 - 7384
See also references of EP 1767646A4
YOSHIKAWA F. ET AL.: "Mutational Analysis of the Ligand Binding Site of the Inositol 1,4,5-Triphosphate Receptor.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 30, 1996, pages 1877 - 18284, XP002991091
TANIMURA A. ET AL.: "Fluorescent Biosensor for Quantitative Real-time Measurements of Inositol 1,4,5-Triophosphate in Signal Living Cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 279, no. 37, 10 September 2004 (2004-09-10), pages 38095 - 38098, XP002991314
NEZU ET AL., J PHARMACOLOGICAL SCIENCE, vol. 94, 2004, pages 138
YOSHIKAWA ET AL., J BIOL CHEM, vol. 271, 1996, pages 18277 - 18284
SCIENCE, vol. 284, 1999, pages 1527 - 1530
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 7380 - 7384
See also references of EP 1767646A4
Attorney, Agent or Firm:
Nishizawa, Toshio (11-1 Minami-Aoyama 6-chom, Minato-ku Tokyo, JP)
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