Title:
PROBE FOR SPECIFICALLY DETECTING PATHOLOGICAL COLLAGENS, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/135437
Kind Code:
A1
Abstract:
Provided are a polypeptide probe for specifically detecting pathological collagens, and a preparation method therefor and the use thereof. The polypeptide probe contains a polypeptide sequence (Gly-Hyp-Pro) n and a signal molecule modified at the N-terminus thereof. The polypeptide probe of the present application can maintain a 100% single-chain structure, and the concentration thereof can be accurately quantified, and the polypeptide probe can thus be used for early diagnosis and efficacy evaluation of collagen-related diseases.
Inventors:
XIAO JIANXI (CN)
CAI XIANGDONG (CN)
CAI XIANGDONG (CN)
Application Number:
PCT/CN2020/117354
Publication Date:
July 08, 2021
Filing Date:
September 24, 2020
Export Citation:
Assignee:
UNIV LANZHOU (CN)
International Classes:
C07K1/04; G01N33/68; C07K1/13; C07K14/00
Foreign References:
| CN107266562A | 2017-10-20 | |||
| CN110129029A | 2019-08-16 | |||
| CN110333354A | 2019-10-15 | |||
| CN107530454A | 2018-01-02 |
Other References:
HWANG JEONGMIN, HUANG YUFENG, BURWELL TIMOTHY J., PETERSON NORMAN C., CONNOR JANE, WEISS STEPHEN J., YU S. MICHAEL, LI YANG: "In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 11, no. 10, 24 October 2017 (2017-10-24), US, pages 9825 - 9835, XP055826101, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b03150
Attorney, Agent or Firm:
BEIJING POWER PATENT AGENCY FIRM (CN)
Download PDF: