Title:
PROBIOTIC COMPOSITION FOR TREATING RAPID EYE MOVEMENT SLEEP BEHAVIOR DISORDER, FORMULATION AND USE
Document Type and Number:
WIPO Patent Application WO/2021/204279
Kind Code:
A1
Abstract:
A probiotic composition for treating rapid eye movement sleep behavior disorder, being prepared from Bacillus licheniformis, Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis, and pharmaceutically acceptable adjuvants. The probiotic composition can improve the symptoms of rapid eye movement sleep behavior disorder of a patient, improve RBD symptoms of idiopathic RBD patients and PD patients, and reduce the dosage of levodopa in PD patients.
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Inventors:
TUO HOUZHEN (CN)
DU YITONG (CN)
XU XIAOJIAO (CN)
LI YUE (CN)
ZHANG MINGKAI (CN)
CUI YING (CN)
XUE YUN (CN)
GAO DAN (CN)
GAO TING (CN)
SHENG ZHI (CN)
DU YITONG (CN)
XU XIAOJIAO (CN)
LI YUE (CN)
ZHANG MINGKAI (CN)
CUI YING (CN)
XUE YUN (CN)
GAO DAN (CN)
GAO TING (CN)
SHENG ZHI (CN)
Application Number:
PCT/CN2021/086312
Publication Date:
October 14, 2021
Filing Date:
April 10, 2021
Export Citation:
Assignee:
BEIJING FRIENDSHIP HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV (CN)
International Classes:
A61K35/747; A61K35/741; A61K35/742; A61K35/745; A61P25/16; A61P25/20
Foreign References:
| CN111297915A | 2020-06-19 | |||
| CN102202527A | 2011-09-28 | |||
| CN102727530A | 2012-10-17 | |||
| CN102065710A | 2011-05-18 | |||
| CN110367543A | 2019-10-25 | |||
| CN110720638A | 2020-01-24 | |||
| CN102356912A | 2012-02-22 |
Other References:
LI WEI, HU XU, WANG TAO, QIN BIN, JIN FENG: "Parkinson′s Disease and Gut Microbiota", CHINESE JOURNAL OF MICROECOLOGY, CHINESE PREVENTIVE MEDICINE ASSOCIATION; DALIAN MEDICAL UNIVERSITY, CN, vol. 29, no. 7, 15 July 2017 (2017-07-15), CN , XP055856246, ISSN: 1005-376X, DOI: 10.13381/j.cnki.cjm.201707024
"Studies on Formation of Lactic Acid and Growth of Bacillus Licheniformis by Biotin Variation", CHINESE JOURNAL OF BIOTECHNOLOGY, January 1998 (1998-01-01)
"Optimization of Bifidobacterium Longum Enrichment Medium", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, no. 04, 2004
"Optimization of Lactobacillus Acidophilus Enrichment Medium", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, no. 06, 2002
"Study on Health Care Yogurt Starter for Lactobacillus Acidophilus and Streptococcus Faecalis", JOURNAL OF ANHUI AGRICULTURAL TECHNOLOGY NORMAL UNIVERSITY, no. 01, 2000
"Optimization of Bacillus Licheniformis 10236 Fermentation Conditions", JOURNAL OF HEBEI AGRICULTURAL SCIENCE, no. 05, 2019
"Optimization of Liquid Fermentation Conditions and Determination of Growth Curve for Bifidobacterium Longum", PREPARATION AND TECHNOLOGY, vol. 9, no. 31, November 2012 (2012-11-01)
"Development of Lyoprotectant for Lactobacillus Acidophilus and Derived Direct-Vat-Set Composite Culture", MODERN FOOD SCIENCE TECHNOLOGY, vol. 35, no. 09, 2019, pages 248 - 257
"Optimization of Encapsulated Fermentation Medium for Enterococcus Faecalis by Response Surface Method", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, no. 21, 2019
STIASNY-KOLSTER KMAYER GSCHAFER S ET AL.: "The REM sleep behavior disorder screening questionnaire - a new diagnostic instrument", MOV DISORD, vol. 22, no. 16, 2007, pages 2386 - 2393
SHEN SSSHEN YXIONG KPCHEN JMAO CJHUANG JYLI JHAN FLIU CF: "Validation study of REM sleep behavior disorder questionnaire-Hong Kong (RBDQ-HK) in east China", SLEEP MED, vol. 15, no. 8, August 2014 (2014-08-01), pages 952 - 8
See also references of EP 4134090A4
"Studies on Formation of Lactic Acid and Growth of Bacillus Licheniformis by Biotin Variation", CHINESE JOURNAL OF BIOTECHNOLOGY, January 1998 (1998-01-01)
"Optimization of Bifidobacterium Longum Enrichment Medium", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, no. 04, 2004
"Optimization of Lactobacillus Acidophilus Enrichment Medium", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, no. 06, 2002
"Study on Health Care Yogurt Starter for Lactobacillus Acidophilus and Streptococcus Faecalis", JOURNAL OF ANHUI AGRICULTURAL TECHNOLOGY NORMAL UNIVERSITY, no. 01, 2000
"Optimization of Bacillus Licheniformis 10236 Fermentation Conditions", JOURNAL OF HEBEI AGRICULTURAL SCIENCE, no. 05, 2019
"Optimization of Liquid Fermentation Conditions and Determination of Growth Curve for Bifidobacterium Longum", PREPARATION AND TECHNOLOGY, vol. 9, no. 31, November 2012 (2012-11-01)
"Development of Lyoprotectant for Lactobacillus Acidophilus and Derived Direct-Vat-Set Composite Culture", MODERN FOOD SCIENCE TECHNOLOGY, vol. 35, no. 09, 2019, pages 248 - 257
"Optimization of Encapsulated Fermentation Medium for Enterococcus Faecalis by Response Surface Method", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, no. 21, 2019
STIASNY-KOLSTER KMAYER GSCHAFER S ET AL.: "The REM sleep behavior disorder screening questionnaire - a new diagnostic instrument", MOV DISORD, vol. 22, no. 16, 2007, pages 2386 - 2393
SHEN SSSHEN YXIONG KPCHEN JMAO CJHUANG JYLI JHAN FLIU CF: "Validation study of REM sleep behavior disorder questionnaire-Hong Kong (RBDQ-HK) in east China", SLEEP MED, vol. 15, no. 8, August 2014 (2014-08-01), pages 952 - 8
See also references of EP 4134090A4
Attorney, Agent or Firm:
BEIJING GENIUS ESSEN INTELLECTUAL PROPERTY OFFICE (CN)
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