Title:
PROCESS AND APPARATUS FOR FREEZING IN PLATES TO OBTAIN ICE MATRIXES WITH A UNIFORM DISTRIBUTION OF SOLUTES
Document Type and Number:
WIPO Patent Application WO/2012/070962
Kind Code:
A3
Abstract:
This invention is a controlled freezing process and an apparatus that aims to attenuate the effect of cryoconcentration of solutes that occurs during the freezing of aqueous solutions, by means of a freezing method that gives the user an adequate control of the speed and of the direction of the interface between the solid and the liquid phases in order to incorporate the solutes uniformly in the ice matrix. This invention has applications in the pharmaceutical industry, the food industry and also in the industry for development and commercialization of cryogenic technology.
Inventors:
RODRIGUES MIGUEL ANGELO JOAQUIM (PT)
BALZAN GUSTAVO BRUZUAL (SE)
FERNANDEZ VITOR MANUEL GERALDES (PT)
MATOS HENRIQUE ANIBA SANTOS DE (PT)
AZEVEDO EDMUNDO JOSE SIMOES GOMES DE (PT)
BALZAN GUSTAVO BRUZUAL (SE)
FERNANDEZ VITOR MANUEL GERALDES (PT)
MATOS HENRIQUE ANIBA SANTOS DE (PT)
AZEVEDO EDMUNDO JOSE SIMOES GOMES DE (PT)
Application Number:
PCT/PT2011/000040
Publication Date:
August 02, 2012
Filing Date:
November 25, 2011
Export Citation:
Assignee:
INST SUPERIIOR TECNICO (PT)
UNIV DO ALGARVE (PT)
UNIV LISBOA (PT)
RODRIGUES MIGUEL ANGELO JOAQUIM (PT)
BALZAN GUSTAVO BRUZUAL (SE)
FERNANDEZ VITOR MANUEL GERALDES (PT)
MATOS HENRIQUE ANIBA SANTOS DE (PT)
AZEVEDO EDMUNDO JOSE SIMOES GOMES DE (PT)
UNIV DO ALGARVE (PT)
UNIV LISBOA (PT)
RODRIGUES MIGUEL ANGELO JOAQUIM (PT)
BALZAN GUSTAVO BRUZUAL (SE)
FERNANDEZ VITOR MANUEL GERALDES (PT)
MATOS HENRIQUE ANIBA SANTOS DE (PT)
AZEVEDO EDMUNDO JOSE SIMOES GOMES DE (PT)
International Classes:
A23B4/06; A23L3/36; C07K14/805; F25D11/04; F25D31/00
Domestic Patent References:
| WO2003037083A1 | 2003-05-08 | |||
| WO2000072902A1 | 2000-12-07 |
Foreign References:
| EP1407202A1 | 2004-04-14 | |||
| US20020177119A1 | 2002-11-28 |
Other References:
BUTLER, M., F.: "Growth of Solutal Ice Dendrites Studied by Optical Inferferometry", CRYSTAL GROWTH AND DESIGN, vol. 2, no. 1, 12 December 2001 (2001-12-12), pages 59 - 66, XP002675118
DATABASE WPI Week 199139, Derwent World Patents Index; AN 1991-285196, XP002675119
BHATNAGAR B., S. ET AL: "Post-Thaw Aging Affects Activity of Lactate Dehydrogenase", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 94, no. 6, June 2005 (2005-06-01), XP002675121
RODRIGUES M. A. ET AL: "Effect of Freezing Rate and Dendritic Ice Formation on Concentration Profiles of Proteins Frozen in Cylindrical Vessels", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 4, 9 December 2010 (2010-12-09), pages 1316 - 1329, XP002675120
DATABASE WPI Week 199139, Derwent World Patents Index; AN 1991-285196, XP002675119
BHATNAGAR B., S. ET AL: "Post-Thaw Aging Affects Activity of Lactate Dehydrogenase", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 94, no. 6, June 2005 (2005-06-01), XP002675121
RODRIGUES M. A. ET AL: "Effect of Freezing Rate and Dendritic Ice Formation on Concentration Profiles of Proteins Frozen in Cylindrical Vessels", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 4, 9 December 2010 (2010-12-09), pages 1316 - 1329, XP002675120
Attorney, Agent or Firm:
SERRA, António Manuel da Cruz (Av. Rovisco Pais, 1049-001 Lisboa, PT)
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