Process for the hydrogenation of imines

The present invention relates to a process for the hydrogenation of imines with hydrogen and with iridium-diphosphine complexes under elevated pressure in the presence of solid acids.

US-A-4994615 describes a process for the asymmetric hydrogenation of prochiral N-arylketimines wherein iridium catalysts having chiral diphosphine ligands are used. US -A-5 Oil 995 describes a process for the asymmetric hydrogenation of prochiral N-alkylketimines using the same catalysts. US-A-5 112999 discloses polynuclear iridium compounds and a complex salt of iridium, which contain diphosphine ligands, as catalysts for the hydrogenation of imines. US-A-5 371 256 and EP-A-0612758 describe iridium complexes with chiral ferrocenyldiphosphine ligands for the homogeneous enantio¬ selective hydrogenation of imines.

Those homogeneous catalysis processes have proved valuable, although it is evident, espe¬ cially in the case of relatively large batches or on an industrial scale, that the catalysts fre¬ quently tend to become deactivated to a greater or lesser extent depending on the catalyst precursor, the substrate and the diphosphine ligands that are used. In many cases, espe¬ cially at elevated temperatures - for example at temperatures >25°C, which are necessary for a short reaction time - it is not possible to achieve complete conversion. For industrial applications of the hydrogenation processes, therefore, the catalyst productivity is too low to be economically viable. Those disadvantages are also not eliminated by the addition of metal halides described in US-A-4994615, US-A-5 011 995 and US-A-5 112 999.

It has now been found, surprisingly, that the catalyst activity can be considerably increased if the reaction mixture contains solid acids. It has also unexpectedly been found that at the same time the deactivation of the catalysts can be considerably reduced or completely eliminated. It has also been found, surprisingly, that when asymmetric catalysts are used the enantioselectivity is high, and high optical yields of up to 80 % can be achieved, even at reaction temperatures of more than 50°C. In addition, it is of particular advantage to the working-up of the reaction mixture that the solid acids can be removed from the reaction mixture simply by filtration. It has also unexpectedly been found that it is even possible to obtain higher conversion rates and optical yields using a smaller amount of catalyst, which offers very considerable economic advantages since the molar ratio of imine to iridium catalyst can be greatly increased.

The invention relates to a process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts containing diphosphine ligands, with or without an inert solvent, the reaction mixture containing a soluble ammonium chloride, bromide or iodide or a metal chloride, bromide or iodide, wherein the reaction mixture additionally contains at least one solid acid with the exception of ion exchangers.

Suitable imines are especially those which contain at least one _/ ^C=N — group. If the groups are substituted asymmetrically and are thus compounds having a prochiral ketimine group, it is possible in the process according to the invention for mixtures of optical isomers or pure optical isomers to be formed if enantioselective or diastereo¬ selective iridium catalysts are used. The imines may contain further chiral carbon atoms. The free bonds in the above formulae may be saturated with hydrogen or organic radicals having from 1 to 22 carbon atoms or organic hetero radicals having from 1 to 20 carbon atoms and at least one hetero atom from the group O, S, N and P. The nitrogen atom of the group may also be saturated with NH ₂ or a primary amino group having from 1 to 22 carbon atoms or a secondary amino group having from 2 to 40 carbon atoms. The organic radicals may be substituted, for example, by F, Cl, Br, Q-Qhaloalkyl wherein halogen is preferably F or Cl, -CN, -NO ₂ , -CO ₂ H, -CONH ₂ , -SO ₃ H, -PO ₃ H ₂ , or by C _r C ₁₂ alkyl esters, phenyl esters or benzyl esters of the groups -CO ₂ H, -SO ₃ H and -PO ₃ H ₂ . Aldimine and ketimine groups are especially reactive, with the result that using the process according to the invention it is possible selectively to hydrogenate groups.

Aldimine and ketimine groups are also to be understood to include hydrazone groups.

The process according to the invention is suitable especially for the hydrogenation of aldimines, ketimines and hydrazones with the formation of corresponding amines and hydrazines, respectively. The ketimines are preferably N-substituted. It is preferable to use chiral iridium catalysts and to hydrogenate enantiomerically pure, chiral or prochiral ketimines to prepare optical isomers, the optical yields (enantiomeric excess, ee) being, for example, higher than 30 %, preferably higher than 50 %, and yields of more than 90 % being achievable. The optical yield indicates the ratio of the two stereoisomers formed, which ratio may be, for example, greater than 2: 1 and is preferably greater than 4: 1.

The imines are preferably imines of formula I

which are hydrogenated lo foπn amines of formula II

R ₂

wherein

R ₃ is preferably a substituent and wherein

R ₃ is linear or branched C ₁ -C ₁₂ alkyl, cycloalkyl having from 3 to 8 ring carbon atoms; heterocycloalkyl bonded via a carbon atom and having from 3 to 8 ring atoms and 1 or 2 hetero atoms from the group O, S and NRg; a C ₇ -C ₁₆ aralkyl bonded via an alkyl carbon atom or Cj-C ₁₂ alkyl substituted by the mentioned cycloalkyl or heterocycloalkyl or heteroaryl; or wherein

R ₃ is C ₆ -C ₁₂ aryl, or C ₄ -C _π heteroaryl bonded via a ring carbon atom and having 1 or 2 hetero atoms in the ring; R ₃ being unsubstituted or substituted by -CN, -NO ₂ , F, Cl,

C _r C ₁₂ alkyl, C _r C ₁₂ alkoxy, C,-C ₁₂ alkylthio, C _r C ₆ haloalkyl, -OH, C ₆ -C ₁₂ -aryl or

-aryloxy or -arylthio, C ₇ -C ₁₆ -aralkyl or -aralkoxy or -aralkylthio, secondary amino having from 2 to 24 carbon atoms, -CONR ₄ R ₅ or by -COOR ₄ , and the aryl radicals and the aryl groups in the aralkyl, aralkoxy and aralkylthio in turn being unsubstituted or substimted by

-CN, -NO ₂ , F, Cl, C,-C ₄ -alkyl, -alkoxy or -alkylthio, -OH, -CONR ₄ R ₅ or by -COOR ₄ ;

R ₄ and R ₅ are each independently of the other hydrogen, C _r C ₁₂ alkyl, phenyl or benzyl, or

R ₄ and R ₅ together are tetra- or penta-methylene or 3-oxapentylene;

R ₆ has independently the same meaning as given for R ₄ ;

Rt and R ₂ are each independently of the other a hydrogen atom, C _r C ₁₂ alkyl or cycloalkyl having from 3 to 8 ring carbon atoms, each of which is unsubstituted or substimted by

-OH, C _r Cι ₂ alkoxy, phenoxy, benzyloxy, secondary amino having from 2 to 24 carbon

atoms, -CONR ₄ R ₅ or by -COOR ₄ ; C ₆ -C ₁₂ aryl or C ₇ -C ₁₆ aralkyl that is unsubstituted or substituted as R ₃ , or -CONR ₄ R ₅ or -COOR ₄ , wherein R ₄ and R ₅ are as defined hereinbefore; or

R ₃ is as defined hereinbefore and Rt and R ₂ together are alkylene having from 2 to 5 carbon atoms that is optionally interrupted by 1 or 2 -O-, -S- or -NR ₆ - radicals, and/or unsubstituted or substituted by =O or as Ri and R ₂ above in the meaning of alkyl, and/or condensed with benzene, pyridine, pyrimidine, furan, thiophene or pyrrole; or

R ₂ is as defined hereinbefore and Ri and R ₃ together are alkylene having from 2 to 5 carbon atoms that is optionally interrupted by 1 or 2 -O-, -S- or -NR ₆ - radicals, and/or unsubstituted or substituted by =O or as R. and R ₂ above in the meaning of alkyl, and/or condensed with benzene, pyridine, pyrimidine, furan, thiophene or pyrrole.

The radicals Ri, R ₂ and R ₃ may contain one or more centres of chirality.

Ri, R ₂ and R ₃ may be substituted in any desired positions by identical or different radicals, for example by from 1 to 5, preferably from 1 to 3, substituents.

Suitable substituents for Ri and R ₂ and R ₃ are: C _r C ₁₂ -, preferably C _r C ₆ -, and especially C _r C ₄ -alkyl, -alkoxy or -alkylthio, e.g. methyl, ethyl, propyl, n-, iso- and tert-butyl, the isomers of pentyl, hexyl, octyl, nonyl, decyl, undecyl and dodecyl, and corresponding alkoxy and alkylthio radicals;

C _r C ₆ haloalkyl, preferably C _r C ₄ haloalkyl, having preferably F and Cl as halogen, e.g. tri- fluoro- or trichloro-methyl, difluorochloromethyl, fluorodichloromethyl, 1,1-difluoro- eth-l-yl, 1,1-dichloroeth-l-yl, 1,1,1 -trichloro- or l,l,l-trifluoro-eth-2-yl, pentachloroethyl, pentafluoroethyl, l,l,l-trifluoro-2,2-dichloroethyl, n-perfluoropropyl, iso-perfluoropropyl, n-perfluorobutyl, fluoro- or chloro-mefhyl, difluoro- or dichloro-mefhyl, 1 -fluoro- or l-chloro-eth-2-yl or -eth-l-yl, 1-, 2- or 3-fluoro- or 1-, 2- or 3-chloro-prop-l-yl or -prop-2-yl or -prop-3-yl, 1 -fluoro- or 1-chloro-but-l-yl, -but-2-yl, -but-3-yl or -but-4-yl, 2,3-dichloro-prop- 1 -yl, 1 -chloro-2-fluoro-prop-3-yl, 2,3-dichlorobut- 1 -yl; C ₆ -C ₁₂ -aryl, -aryloxy or -arylthio, in which aryl is preferably naphthyl and especially phenyl, C ₇ -C ₁₆ -aralkyl, -aralkoxy and -aralkylthio, in which the aryl radical is preferably naphthyl and especially phenyl and the alkylene radical is linear or branched and contains from 1 to 10, preferably from 1 to 6 and especially from 1 to 3, carbon atoms, for example benzyl, naphthy lmethyl, 1- or 2-phenyl-eth-l-yl or -eth-2-yl, 1-, 2- or 3-phenyl-prop-l-yl,

-prop-2-yl or -prop-3-yl, with benzyl being especially preferred; the radicals containing the aryl groups mentioned above may in turn be mono- or poly¬ substituted, for example by C _r C ₄ -alkyl, -alkoxy or -alkylthio, halogen, -OH, -CONR ₄ R ₅ or by -COOR ₅ , wherein R ₄ and R ₅ are as defined; examples are methyl, ethyl, n- and iso¬ propyl, butyl, corresponding alkoxy and alkylthio radicals, F, Cl, Br, dimethyl-, methyl¬ ethyl- and diethyl-carbamoyl and methoxy-, ethoxy-, phenoxy- and benzyloxy-carbonyl;

halogen, preferably F and Cl;

secondary amino having from 2 to 24, preferably from 2 to 12 and especially from 2 to 6, carbon atoms, the secondary amino preferably containing 2 alkyl groups, for example dimethyl-, methylethyl-, diethyl-, methy Ipropyl-, methyl-n-butyl-, di-n-propyl-, di-n-butyl- or di-n-hexyl-amino;

-CONR ₄ R ₅ , wherein R ₄ and R ₅ are each independently of the other C _r C ₁₂ alkyl, prefer¬ ably Cj-C ₆ alkyl, and especially Q-Qalkyl, or R ₄ and R ₅ together are tetra- or penta¬ methylene or 3-oxapentylene, the alkyl being linear or branched, e.g. dimethyl-, methyl¬ ethyl-, diethyl-, methyl-n-propyl-, ethyl-n-propyl-, di-n-propyl-, methyl-n-butyl-, ethyl-n- butyl-, n-propyl-n-butyl- and di-n-butyl-carbamoyl;

-COOR ₄ , wherein R ₄ is Q-Q ₂ alkyl, preferably Q-C ₆ alkyl, which may be linear or branched, e.g. methyl, ethyl, n- and iso-propyl, n-, iso- and tert-butyl, and the isomers of pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl and dodecyl.

Ri, R ₂ and R ₃ may contain especially functional groups, such as keto groups, -CN, -NO ₂ , carbon double bonds, N-O-, aromatic halogen groups and amide groups.

R _j and R ₂ as heteroaryl are preferably a 5- or 6-membered ring having 1 or 2 identical or different hetero atoms, especially O, S or N, which contains preferably 4 or 5 carbon atoms and can be condensed with benzene. Examples of heteroaromatics from which Ri can be derived are furan, pyrrole, thiophene, pyridine, pyrimidine, indole and quinoline.

Ri and R ₂ as heteroaryl-substituted alkyl are derived preferably from a 5- or 6-membered ring having 1 or 2 identical or different hetero atoms, especially O, S or N, which contains preferably 4 or 5 carbon atoms and can be condensed with benzene. Examples of hetero¬ aromatics are furan, pyrrole, thiophene, pyridine, pyrimidine, indole and quinoline.

Rι and R ₂ as heterocycloalkyl or as heterocycloalkyl-substituted alkyl contain preferably from 4 to 6 ring atoms and 1 or 2 identical or different hetero atoms from the group O, S and NR ₆ . It can be condensed with benzene. It may be derived, for example, from pyrrol¬ idine, tetrahydrofuran, tetrahydrothiophene, indane, pyrazolidine, oxazolidine, piperidine, piperazine or morpholine.

Ri, R ₂ and R ₃ as alkyl are preferably unsubstituted or substituted Q-Qalkyl, especially Q-Qalkyl, which may be linear or branched. Examples are methyl, ethyl, iso- and n-propyl, iso-, n- and tert-butyl, the isomers of pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl and dodecyl.

Ri, R ₂ and R ₃ as unsubstituted or substituted cycloalkyl contain preferably from 3 to 6, especially 5 or 6, ring carbon atoms. Examples are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.

Ri, R ₂ and R ₃ as aryl are preferably unsubstituted or substituted naphthyl and especially phenyl. R, , R ₂ and R ₃ as aralkyl are preferably unsubstimted or substituted phenylalkyl having from 1 to 10, preferably from 1 to 6 and especially from 1 to 4, carbon atoms in the alkylene, the alkylene being linear or branched. Examples are especially benzyl, and 1-phenyleth-l-yl, 2-phenyleth-l-yl, 1-phenylprop-l-yl, l-phenylprop-2-yl, 1-phenyl- prop-3-yl, 2-phenylprop-l-yl, 2-phenylprop-2-yl and l-phenylbut-4-yl.

In R ₂ and R ₃ as -CONR ₄ R ₅ and -COOR ₄ , R ₄ and R ₅ are preferably Q-Qalkyl, especially Q-Qalkyl, or R ₄ and R ₅ together are tetramethylene, pentamethylene or 3-oxapentylene. Examples of alkyl have been mentioned hereinbefore.

R _j and R ₂ together or Rj and R ₃ together as alkylene are preferably interrupted by one -O-, -S- or -NR ₆ - radical, preferably -O-. Ri and R ₂ together or Ri and R ₃ together form, with the carbon atom or with the -N=C group to which they are bonded, respectively, preferably a 5- or 6-membered ring. For the substiments the preferences mentioned herein¬ before apply. As condensed alkylene, Ri andR ₂ together or R, and R ₃ together are prefer¬ ably alkylene condensed with benzene or pyridine. Examples of alkylene are: ethylene, 1,2- or 1,3-propylene, 1,2-, 1,3- or 1,4-butylene, 1,5-pentylene and 1,6-hexylene. Examples of interrupted or ^■ _" ^■■ O-substituted alkylene are 2-oxa-l,3-propylene, 2-oxa-l,4- butylene, 2-oxa- or 3-oxa-l,5-pentylene, 3-thia-l,5-pentylene, 2-thia-l,4-butylene, 2-thia-

1,3-propylene, 2-methylimino-l,3-propylene, 2-ethylimino-l,4-butylene, 2- or 3-methyl- imino-l,5-pentylene, l-oxo-2-oxa-l,3-propylene, l-oxo-2-oxa-l,4-butylene, 2-oxo-3-oxa- 1,4-butylene, l-oxa-2-oxo-l,5-pentylene. Examples of condensed alkylene are:

Examples of condensed and interrupted and unsubstituted or ■=O-substituted alkylene are:

R ₄ and R ₅ are preferably each independently of the other hydrogen, Q-Qalkyl, phenyl or benzyl. Rg is preferably hydrogen or Q-Qalkyl.

A further preferred group is formed by prcchiral imines in which in formula I Ri, R ₂ and R ₃ are each different from the others and are not hydrogen.

In an especially preferred group, in formula I R ₃ is 2,6-di-Q-Qalkylphen-l-yl and espe¬ cially 2,6-dimethylphen-l-yl or 2-methyl-6-ethylphen-l-yl, R _j is Q-Qalkyl and espe¬ cially ethyl or methyl, and R ₂ is Q-Qalkyl, Q-Qalkoxymethyl or Q-Qalkoxyethyl, and especially methoxymethyl.

Of those compounds, imines of formulae

(Vb) are especially

important, as is the imine of formula

Imines of formula I are known or they can be prepared in accordance with known processes from aldehydes or ketones and primary amines.

The iridium catalysts are preferably homogeneous catalysts that are substantially soluble in the reaction medium. The term "catalyst" also includes catalyst precursors that are converted into an active catalyst species at the beginning of a hydrogenation. The catalysts preferably correspond to the formulae III, Ilia, lllb, IIIc and Hid,

[XlrYZ] (UI), [XIrY] ^θ A ^θ (Ilia),

[YIrZ ₄ ] ^θ M ^θ (Lllb), [YlrHZ^ (IIIc),

[YlrZy, (DM),

wherein X is two olefin ligands or a diene ligand, Y is a ditertiary diphosphine

(a) the phosphine groups of which are bonded to different carbon atoms of a carbon chain having from 2 to 4 carbon atoms, or

(b) the phosphine groups of which are either bonded directly or via a bridge group -CR _a R _b - in the ortho positions of a cyclopentadienyl ring or are each bonded to a cyclo¬ pentadienyl ring of a ferrocenyl, or

(c) one phosphine group of which is bonded to a carbon chain having 2 or 3 carbon atoms and the other phosphine group of which is bonded to an oxygen atom or nitrogen atom bonded terminally to that carbon chain, or

(d) the phosphine groups of which are bonded to the two oxygen atoms or nitrogen atoms bonded terminally to a C ₂ -carbon chain; with the result that in the cases of (a), (b), (c) and (d) a 5-, 6- or 7-membered ring is formed with the Ir atom, the radicals Z are each independently of the other(s) Cl, Br or I, A® is the anion of an oxy or complex acid, and M® is an alkali metal cation or quaternary ammonium, and R _a and R _b are each independently of the other hydrogen, Q-Qalkyl, Q-Qfluoroalkyl, phenyl or benzyl, or phenyl or benzyl having from 1 to 3 Q-Qalkyl or Q-Qalkoxy substituents. R _b is preferably hydrogen. R _a is preferably Q-Qalkyl and

especially methyl.

The diphosphine Y contains preferably at least one chiral group and is especially an optically pure stereoisomer or a pair of diastereoisomers, since the use of catalysts containing chiral ligands leads to optical induction in asymmetric hydrogenation reactions.

X as an olefin ligand may be a branched or, preferably, linear C ₂ -Q ₂ alkylene, especially Q-Qalkylene. Some examples are dodecylene, decylene, octylene, 1-, 2- or 3-hexene, 1-, 2- or 3-pentene, 1- or 2-butene, propene and ethene. X as a diene ligand may be an open- chain or cyclic diene having from 4 to 12, preferably from 5 to 8, carbon atoms, the diene groups preferably being separated by one or two saturated carbon atoms. Some examples are butadiene, pentadiene, hexadiene, heptadiene, octadiene, decadiene, dodecadiene, cyclopentadiene, cyclohexadiene, cycloheptadiene, cyclooctadiene and bridged cyclo- dienes such as norbornadiene and bicyclo-2,2,2-octadiene. Hexadiene, cyclooctadiene and norbornadiene are preferred.

The phosphine groups contain preferably two identical or different, preferably identical, unsubstimted or substituted hydrocarbon radicals having from 1 to 20, especially from 1 to 12, carbon atoms. Preference is given to those diphosphines wherein the secondary phosphine groups contain two identical or different radicals from the following group: linear or branched Q-C ₁₂ alkyl; unsubstimted or Q-Qalkyl- or Q-Qalkoxy-substiruted Q-Q ₂ cycloalkyl, Q-C ₁₂ cycloalkyl-CH ₂ -, phenyl or benzyl; and phenyl or benzyl substi¬ tuted by halogen (e.g. F, Cl or Br), Q-Qhaloalkyl, (Q-C ₁₂ alkyl) ₃ Si, (QH ₅ ) ₃ Si, Q-Qhaloalkoxy (e.g. trifluoromethoxy), -NH ₂ , phenyl ₂ N-, benzyl ₂ N-, morpholinyl, piperidinyl, pyrrolidinyl, (Q-Q ₂ alkyι) ₂ N-, -ammonium-X,®, -SO ₃ M,, -CO ₂ Mι, -PO ₃ M, or by -COO-Q-Qalkyl (e.g. -COOCH ₃ ), wherein Mi is an alkali metal or hydrogen and X _j ® is the anion of a monobasic acid. i is preferably H, Li, Na or K. Ai® as the anion of a monobasic acid is preferably Cl®, Br® or the anion of a carboxylic acid, for example formate, acetate, trichloroacetate or trifluoroacetate.

Examples of alkyl that preferably contains from 1 to 6 carbon atoms are methyl, ethyl, n-propyl, isopropyl, n-, iso- and tert-butyl and the isomers of pentyl and hexyl. Examples of unsubstimted or alkyl-substituted cycloalkyl are cyclopentyl, cyclohexyl, methyl- or ethyl-cyclohexyl and dimethylcyclohexyl. Examples of alkyl-, alkoxy- or haloalkoxy- substituted phenyl and benzyl are methylphenyl, dimethylphenyl, trimethylphenyl, ethyl- phenyl, methylbenzyl, methoxyphenyl, dimethoxyphenyl, trifluoromethylphenyl, bis-tri-

fluoromethylphenyl, tris-trifluoromethylphenyl, trifluoromethoxyphenyl and bis-trifluoro- methoxyphenyl. Preferred phosphine groups are those which contain identical or different, preferably identical, radicals from the group Q-Qalkyl; cyclopentyl and cyclohexyl that are unsubstituted or have from one to three Q-Qalkyl or Q-Qalkoxy substiments, benzyl and, especially, phenyl that are unsubstituted or have from one to three Q-Qalkyl, Q-Qalkoxy, F, Cl, Q-Qfluoroalkyl or Q-Qfluoroalkoxy substituents.

A secondary phosphine group may also be a radical of the formula

, wherein

m and n are each independently of the other an integer from 2 to 10, and the sum of m+n is from 4 to 12, especially from 5 to 8. Examples thereof are [3.3.1]- and [4.2.1]-phobyl of the formulae

A secondary phosphine group may also be a radical of the formula

wherein R ₁₇ is Q-Qalkylene, preferably Q- or Q-alkylene, and R ₁₈ and R ₁₉ are each independently of the other hydrogen, Q-Qalkyl, Q-Qalkoxy, Q-Qhaloalkyl, Q- or Q-cycloalkyl, unsubstimted or Q-Qalkyl-, Q-Qalkoxy-, Q-Qhaloalkyl- or halo¬ substituted phenyl, or unsubstituted or Q-Qalkyl-, Q-Qalkoxy-, Q-Qhaloalkyl- or halo-substituted benzyl. R ₁₈ and R ₁₉ may be, for example, methyl, ethyl, n- or iso-propyl, n-, iso- or tert-butyl, cyclohexyl, phenyl or benzyl.

Y as a diphosphine is preferably of formula IV, IVa, IVb, IVc or IVd,

R ₇ R ₈ P-R ₉ -PR ₁₀ R, , (IV),

R ₇ R ₈ P-O-R, ₂ -PR ₁₀ R, , (IVa),

RvRgP-NR _e -R -PRioR, , (IVb),

R ₇ R ₈ P-O-R ₁₃ -O-PR ₁₀ R ₁₁ (IVc),

R ₇ R ₈ P-NR _C -R ₁₃ -NR _C -PR ₁₀ R ₁ , (IVd),

wherein

R ₇ , R ₈ , R ₁₀ and Ri i are each independently of the others a hydrocarbon radical having from 1 to 20 carbon atoms that is unsubstimted or substituted by Q-Qalkyl, Q-Qalkoxy, halogen, Q-Qhaloalkyl, (Q-C ₁₂ alkyl) ₃ Si, (QH ₅ ) ₃ Si, Q-Qhaloalkoxy, -NH ₂ , phenyl ₂ N-, benzyl ₂ N-, morpholinyl, piperidinyl, pyrrolidinyl, (Q-C ₁₂ alkyl) ₂ N-, -ammonium-X,®, -SO ₃ Mι, -CO ₂ M,, -PO ₃ M, or by -COO-Q-Qalkyl, wherein M, is an alkali metal or hydrogen and X _j ® is the anion of a monobasic acid;

R ₇ and R ₈ together and also R ₁₀ and R _u together form a Q-Qalkylene radical that is unsubstimted or substituted by Q-Qalkyl, by Q-Qalkoxy, by Q-Qhaloalkyl, by Q- or Q-cycloalkyl, by unsubstituted or Q-Qalkyl-, Q-Qalkoxy-, Q-Qhaloalkyl- or halo¬ substituted phenyl or by unsubstituted or Q-Qalkyl-, Q-Qalkoxy-, Q-Qhaloalkyl- or halo-substituted benzyl.

R ₉ is linear Q-Qalkylene that is unsubstimted or substimted by Q-Qalkyl, Q- or Q-cycloalkyl, phenyl, naphthyl or by benzyl; 1,2- or 1,3-cycloalkylene or -cycloalkenyl- ene, -bicycloalkylene or -bicycloalkenylene having from 4 to 10 carbon atoms, each of which is unsubstituted or substimted by Q-Qalkyl, phenyl or by benzyl; 1,2- or 1,3-cycloalkylene or -cycloalkenylene, -bicycloalkylene or -bicycloalkenylene having from 4 to 10 carbon atoms, each of which is unsubstimted or substimted by Q-Qalkyl, phenyl or by benzyl, and in the 1- and or 2-positions or in the 3 -position of which methyl¬ ene or Q-Qalkylidene is bonded; 1,4-butylene substimted in the 2,3-positions by

and unsubstituted or substimted in the 1,4-positions by Q-Qalkyl, phenyl or by benzyl, wherein R ₂₁ and R ₂₂ are each independently of the other hydrogen, Q-Qalkyl, phenyl or benzyl; 3,4- or 2,4-pyrrolidinylene or 2-methylene-pyrrolidin-4-yl the nitrogen atom of which is substimted by hydrogen, Q-C ₁₂ alkyl, phenyl, benzyl, Q-Q ₂ alkoxycarbonyl, Q-Qacyl or by Q-C ₁₂ alkylaminocarbonyl; or 1,2-phenylene, 2-benzylene, 1,2-xylylene, 1,8-naphthylene, 2,2 '-dinaphthylene or 2,2'-diphenylene, each of which is unsubstituted or substimted by Q-Qalkyl;

or R ₉ is a radical of the formula

wherein R ₁₄ is hydrogen, C _r C ₈ alkyl, C _r C ₄ fluoroalkyl, phenyl or phenyl having from 1 to 3 Q-Qalkyl or Q-Qalkoxy substituents;

R ₁₂ is linear Q- or Q-alkylene that is unsubstimted or substituted by Q-Qalkyl, Q- or

C ₆ -cycloalkyl, phenyl, naphthyl or by benzyl; 1,2- or 1,3-cycloalkylene or -cycloalkenyl- ene, -bicycloalkylene or -bicycloalkenylene having from 4 to 10 carbon atoms, each of which is unsubstituted or substimted by Q-Qalkyl, phenyl or by benzyl; or 1,2- or 1,3- cycloalkylene or -cycloalkenylene, -bicycloalkylene or -bicycloalkenylene having from 4 to 10 carbon atoms, each of which is unsubstituted or substimted by Q-Qalkyl, phenyl or by benzyl, and in the 1- and/or 2-positions or in the 3-position of which methylene or Q-Qalkylidene is bonded; 3,4- or 2,4-pyrrolidinylene or 3-methylene-pyrrolidin-4-yl the nitrogen atom of which is substituted by hydrogen, Q-C ₁₂ alkyl, phenyl, benzyl, Q-Q ₂ alkoxycarbonyl, Q-Qacyl or by Q-C ₁₂ alkylaminocarbonyl; or 1,2-phenylene, 2-benzylene, 1,2-, 2,3- or 1,8-naphthylene, each of which is unsubstituted or substituted by Q-Qalkyl; and

R ₁₃ is linear Qalkylene that is unsubstimted or substimted by Q-Qalkyl, Q- or Q-cycloalkyl, phenyl, naphthyl or by benzyl; 1,2-cycloalkylene or -cycloalkenylene, -bicycloalkylene or -bicycloalkenylene having from 4 to 10 carbon atoms, each of which is unsubstituted or substimted by Q-Qalkyl, phenyl or by benzyl; 3,4-pyrrolidinylene the nitrogen atom of which is substituted by hydrogen, Q-Q ₂ alkyl, phenyl, benzyl, Q-Q ₂ alkoxycarbonyl, Q-Qacyl or by Q-C ₁₂ alkylaminocarbonyl; or 1,2-phenylene that is unsubstituted or substimted by Q-Qalkyl, or is a radical, less two hydroxy groups in the ortho positions, of a mono- or di-saccharide, and

R _c is hydrogen, Q-Qalkyl, phenyl or benzyl.

R ₇ , R ₈ , R ₁₀ and R _u are preferably identical or different, preferably identical, radicals from the following group: Q-Qalkyl; cyclopentyl and cyclohexyl that are unsubstituted or have from 1 to 3 Q-Qalkyl or Q-Qalkoxy substiments; benzyl and, especially, phenyl that are unsubstimted or have from 1 to 3 Q-Qalkyl, Q-Qalkoxy, F, Cl, Q-Qfluoro¬ alkyl or Q-Qfluoroalkoxy substituents.

A preferred subgroup of diphosphines DIP is formed by those of the formulae

wherein

R ₁₅ and R ₁₆ are each independently of the other hydrogen, Q-Qalkyl, phenyl, benzyl, or

phenyl or benzyl having from one to three Q-Qalkyl or Q-Qalkoxy substituents,

R _I is hydrogen, Q-Qalkyl, phenyl, benzyl, or phenyl or benzyl having from 1 to 3

Q-Qalkyl or Q-Qalkoxy substiments,

R ₁₇ is hydrogen, Q-Qalkyl, phenyl, benzyl, Q-Qalkoxy-CO-, Q-Qalkyl-CO-, ρhenyl-CO-, naphthyl-CO- or Q-QalkylNH-CO-,

R ₁₀₃ and R ₁₀₄ are hydrogen, Q-Qalkyl or phenyl,

A may represent identical or different groups -P(R) ₂ , wherein R is Q-Qalkyl, cyclohexyl, phenyl, benzyl, or phenyl or benzyl having from 1 to 3 Q-Qalkyl, disubstimted amino,

Q-Qalkoxy, -CF ₃ or partially or fully fluorinated Q-Qalkoxy substituents, and n is 0, 1 or 2. Of those phosphines, chirally substituted compounds are especially preferred.

Some preferred examples of diphosphines Y are (Ph is phenyl):

R _c - H, methyl, phenyl R _j - H, methyl, phenyl

, H,

R _f - Cι-C ₄ alkyl, benzyl

unsubstituted or has from 1 to 3 methyl, disubstituted amino, -CF ₃ or methoxy substituents

Especially suitable diphosphine ligands DIP are those wherein the secondary phosphine groups are either bonded directly or via a bridge group -CR _a R _b - in the ortho positions of a cyclopentadienyl ring or are each bonded to a cyclopentadienyl ring of a ferrocenyl, more especially those of formula X

wherein R ₁₄ is hydrogen, Q-Qalkyl, phenyl, benzyl, or phenyl or benzyl having from one to three Q-Qalkyl or Q-Qalkoxy substituents, and A represents identical or different groups -P(R) ₂ wherein R is Q-Qalkyl, cyclohexyl, phenyl, benzyl, or phenyl or benzyl having from one to three Q-Qalkyl, disubstituted amino, Q-Qalkoxy, -CF ₃ or partially or fully fluorinated Q-Qalkoxy substituents.

Preference is given to a sub-group wherein the diphosphine of formula X is chiral and R ₁₄ is Q-Qalkyl, or is phenyl or benzyl having from one to three Q-Qalkyl or Q-Qalkoxy substiments, and A represents identical or different groups -P(R) ₂ wherein R is Q-Qalkyl, cyclohexyl, phenyl, benzyl, or phenyl or benzyl having from one to three Q-Qalkyl, disubstituted amino, Q-Qalkoxy, -CF ₃ or partially or fully fluorinated Q-Qalkoxy substituents.

Very special preference is given to the following diphosphine ligands which can be used especially in catalysts of formula (III):

{(R)- 1 -[(S)-2-(diphenylphosphino)ferrocenyl] >ethyl-di(3,5-dimethyl-phenyl)phosphine,

{(R)-l-[(S)-2-(diphenylphosphino)ferrocenyl]>ethyl-di( 3,5-dimethyl-4-N,N-dipropyl- aminophenyl)phosphine,

{(R)-l-[(S)-2-(diphenylphosphino)ferrocenyl])ethyl-di(3,5 -di-iso-propyl-4-N,N-dimethyl- aminopheny phosphine,

<(R)-l-[(S)-2-(diphenylphosphino)ferrocenyl])ethyl-di( 3,5-di-iso-propyl-4-N,N-di- benzylylaminophenyl)phosphine,

{(R)-l-[(S)-2-(diphenylphosphino)ferrocenyl])ethyl-di(3,5 -dimethyl-4-N,N-dibenzylyl- aminophenyl)phosphine,

{(R)- 1 -[(S)-2-(diphenylphosphino)ferrocenyl] }ethyl-di(3,5-dimethyl-4-( 1 '-pyrrolo)- phenyl)phosphine,

<(R)-l-[(S)-2-(diphenylphosphino)ferrocenyl]>ethyl- di(3,5-dimethyl-4-N,N-dipentyl- aminophenyl)phosphine,

<(R)-l-[(S)-2-(diphenylphosphino)ferrocenyl])ethyl-di( 3,5-dimethyl-4-N,N-dimethyl- aminophenyl)phosphine,

1 ,4-bis(diphenylphosphino)butane,

{(R)- 1 -[(S)-2-(di(4-methoxyphenyl)phosphino)ferrocenyl] }ethyl-di(3,5-dimethyl-4-N,N- dimethylaminophenyl)phosphine and especially

{(R)-l-[(S)-2-(diphenylphosphino)ferrocenyl]}ethyl-di(3,5 -dimethyl-phenyl)phosphine.

Suitable diphosphines and diphosphinites have been described, for example, by H.B. Kagan in Chiral Ligands for Asymmetric Catalysis, Asymmetric Synthesis, Volume 5, pp. 13-23, Academic Press, Inc., N.Y. (1985). The preparation of ferrocenyl diphosphine ligands is described, for example, in EP-A-0564406 and by T. Hayashi et al. in Bull. Chem. Soc. Jpn., 53, pages 1136-1151.

A® in formula Ilia can be derived from inorganic or organic oxy acids. Examples of such

acids are H ₂ SO ₄ , HClO ₄ , HClO ₃ , HBrO ₄ , HIO ₄ , HNO ₃ , H ₃ PO ₃ , H ₃ PO ₄ , CF ₃ SO ₃ H, C ₆ H ₅ SO ₃ H, CF ₃ COOH and CCl ₃ COOH. Complex acids from which A® can be derived are, for example, the halo complex acids of the elements B, P, As, Sb and Bi. Preferred examples of A® in formula Ilia are ClO ₄ ®, CF ₃ SO ₃ ®, BF ₄ ®, B(phenyl) ₄ ®, PF ₆ ®, SbCl ₆ ®, AsF ₆ ® and SbF ₆ ®.

When M® in formula lllb is an alkali metal cation, it may be, for example, a Li, Na, K, Rb or Cs cation. When M® is quaternary ammonium, it may contain a total of from 4 to 40, preferably from 4 to 24, carbon atoms. M® may correspond to the formula phenylN®(C _r Qalkyl) ₃ , benzylN®(Q-Qalkyl) ₃ or (Q-Qalkyl) ₄ N®. M® in formula IITb is preferably Li®, Na® or K® or (Q-Qalkyl) ₄ N®.

Z in formula III is preferably Br or Cl and especially Cl. Z in formula nib is preferably Br or I and Z in formulae Uie and Hid is preferably I.

The preparation of the catalysts is known per se and is described, for example, in US-A-4994615, US-A-5 011 995, US-A-5 112 999 and EP-A-0564406. The preparation of the catalysts of formula III can be carried out, for example, by reacting a diiridium complex of the formula [IrXZ] ₂ with a diphosphine Y. The iridium catalysts can be added to the reaction mixmre as isolated compounds. It has proved advantageous, however, to produce the catalysts in situ prior to the reaction with or without a solvent and to add optionally a portion or all of the acid and of an ammonium or metal halide.

The molar ratio of imine to iridium catalyst may be, for example, from 5 000000 to 10, especially from 2 000000 to 20, more preferably from 1 000000 to 100, and more espe¬ cially from 1 000000 to 1000.

The molar ratio of imine to solid acid is, for example, from 1 000000 to 100, preferably from 500000 to 500, more especially from 10000 to 1000.

The process is carried out preferably at a temperature of from -20 to 100°C, especially from 0 to 80°C and more especially from 10 to 70°C, and preferably at a hydrogen pressure of 2 x IO ⁵ to 1.5 x 10 ⁷ Pa (5 to 150 bar), especially IO ⁶ to IO ⁷ Pa (10 to 100 bar).

Within the scope of the invention, solid acids are to be understood as being those which are insoluble or only swellable in the reaction medium. Acidic inorganic or organic ion

exchangers are not included, whereas ion exchangers that have been treated with acids do fall within the scope of the invention. Within the scope of the invention a solid acid is to be understood as being a solid, finely particulate and optionally porous material of which 1 g in 100 ml of water gives a pH value of <5, preferably <4 and especially ≤3.

In one embodiment the solid acids may be metal oxide systems in gel form (sol/gel systems), for example SiO ₂ , GeO ₂ , B ₂ O ₃ , Al ₂ O ₃ , TiO ₂ , ZrO ₂ and combinations thereof. When the desired effects are not obtained to the expected extent, a considerable improve¬ ment may be achieved by treating the sol/gel systems with an acid, preferably an at least dibasic acid, such as, for example, H ₂ SO ₄ , H ₃ PO ₄ or orthophosphoric acid. Other suitable acids are, for example, HCl, HBr, HI, HClO ₄ , HBF ₄ , HPF ₆ , HAsF ₆ , HSbCl ₆ , HSbF ₆ and HB(phenyl) ₄ , aliphatic and aromatic optionally halogenated (fluorinated or chlorinated) carboxylic acids, sulfonic acids and phosphorus(V) acids (for example phosphonic acids or phosphonous acids) having preferably from 1 to 20, especially from 1 to 12 and more especially from 1 to 8, carbon atoms, for example formic acid, acetic acid, propionic acid, butyric acid, benzoic acid, phenylacetic acid, cyclohexanecarboxylic acid, mono-, di- and tri-chloroacetic acid, mono-, di- and tri-fluoroacetic acid, chlorobenzoic acid, methane¬ sulfonic acid, ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, chloro- benzenesulfonic acid, trifluoromethanesulfonic acid, methylphosphonic acid and phenyl- phosphonic acid. H ₂ SO is preferred.

In a further embodiment, the solid acids may be inorganic or organic ion exchangers that have been treated with an at least dibasic acid, such as, for example, H ₂ SO , H ₂ S ₂ O ₇ or H ₃ PO ₄ . Ion exchangers are known to the person skilled in the art and are described, for example, in Ullmann's Enzyklopadie der Chemischen Technik, Volume 13, 4th Edition, pages 281 to 284. Organic ion exchangers that may be mentioned are especially polymers having acidic groups, for example -C(O)OH, -SO ₃ H or -PO ₃ H (for example Nafion®), which are commercially available. Inorganic ion exchangers that may be mentioned are especially the natural and synthetic aluminosilicates,for example zeolites, which are described in Studies in Surface Science and Catalysis, Elsevier 1991, Vol. 58, chapter 2, pages 13 to 33. They are commercially available. Examples are Zeolith ZSM-5, Zeolith Y and mordenite.

In another embodiment, the solid acids may be acidic namral or synthetic silicate-like minerals that have no or only limited ion exchanging properties. Examples are phyllo- silicates and argillaceous earths, for example montmorillonite, hectorite, vermicullite,

kaohnite and illite. The silicates and argillaceous earths may additionally be impregnated with an acid, preferably an at least dibasic acid, such as, for example, H ₂ SO ₄ , H ₂ S ₂ O ₇ and H ₃ PO ₄ , which enables the action to be further increased. Other suitable acids have been mentioned above.

In a further embodiment, the solid acids may be heteropoly acids which preferably consist of the elements Mo, V, W, O and H and also B, Si or P and secondary or trace elements. Such heteropoly acids are known and are described, for example, in Chemtech, page 23ff (November 1993) or Russian Chemicals Reviews, page 81 Iff (1987). Some examples are H ₃ PW ₁₂ O ₄ o, H ₉ PV ₆ Mo ₆ O ₄ o, H^iMo^O^ and H ₅ BW ₁₂ O ₄ o.

A further suitable form of the solid acids includes non-acidic, solid, finely particulate and optionally porous carriers that have been impregnated with an acid. Suitable carriers are, for example, organic polymers, such as epoxy resins, urea/aldehyde resins, melamine/- aldehyde resins, polystyrene, ABS and polyolefins. Suitable inorganic carriers are, for example, metal and semi-metal oxides (B ₂ O ₃ , Al ₂ O ₃ , SiO ₂ , TiO , ZrO ₂ ), metal nitrides, metal carbides, minerals such as silicates, and crushed stone. It will be understood that the acids must not react with the carriers. Suitable acids have been mentioned above.

The process according to the invention also comprises the additional concomitant use of a soluble ammonium chloride, bromide or iodide or a soluble metal chloride, bromide or iodide. The chlorides, bromides and iodides are used preferably in amounts of from 0.01 to 200 equivalents, especially from 0.05 to 100 equivalents and more especially from 0.5 to 50 equivalents, based on the iridium catalyst. The iodides are preferred. Ammonium is preferably tetraalkylammonium having from 1 to 6 carbon atoms in the alkyl groups, and the metal is preferably sodium, lithium or potassium. Special preference is given to tetra¬ butylammonium iodide, sodium iodide and potassium iodide. Provided that they are soluble in the reaction mixture and provided that oxidation reactions with other reactants can be ruled out, virtually any metal chlorides, bromides and iodides, that is to say those of the main groups and sub-groups of the Periodic Table of the Elements, can be used in the process according to the invention.

The chlorides, bromides and iodides are preferably used in concentrations of from 0.01 to 500 mmol/litre, especially from 0.01 to 50 mmol litre, based on the volume of the reaction mixmre. When hydrohalic acids, especially HI, are used in the form of solid acids, the addition of the halide is unnecessary because an ammonium salt is formed in situ with the

amine formed.

The reaction can be carried out in the absence or in the presence of solvents. Examples of suitable solvents, which can be used alone or as a mixture of solvents, are:

aliphatic and aromatic hydrocarbons, such as pentane, hexane, cyclohexane, methylcyclo- hexane, benzene, toluene and xylene; ethers, such as diethyl ether, diethylene glycol dimethyl ether, tetrahydrofuran and dioxane; halogenated hydrocarbons, such as methyl¬ ene chloride, chloroform, 1,1,2,2-tetrachloroethane and chlorobenzene; esters and lactones, such as ethyl acetate, butyrolactone and valerolactone; acid amides and lactams, such as dimethylformamide, dimethylacetamide and N-methylpyrrolidone, and ketones, such as acetone, dibutyl ketone, methyl isobutyl ketone and methoxyacetone.

In detail, the process according to the invention can be carried out by first preparing the catalyst by dissolving, for example, (Ir-dieneCl) ₂ and a diphosphine in a solvent or in a portion of the substance to be hydrogenated; the solid acid is then added either directly or in the form of a slurry in a solvent and imine (optionally in the form of a solution). That mixmre is hydrogenated in an autoclave and the reaction mixture is isolated and purified in a manner known per se, for example by precipitation, extraction or distillation. It has proved advantageous to prepare the solid acid together with the components necessary for the catalyst formation and optionally a solvent as the initial batch and then to add the imine and to form the catalyst in situ during the initial phase of the hydrogenation.

Prior to the hydrogenation it is expedient to operate under an inert gas. It is advantageous to ensure that the catalyst solution stands for only a short time, and to carry out the hydrogenation of the imines as soon as possible after the preparation of the catalyst solution.

In the case of the hydrogenation of aldimines and ketimines, the aldimines and ketimines can also be formed in situ before or during the hydrogenation. In a preferred embodiment, an amine and an aldehyde or a ketone are mixed together and added to the catalyst solution and the aldimine or ketimine formed in situ is hydrogenated. It is also possible, however, to use an amine, a ketone or an aldehyde together with the catalyst as the initial batch and then to add the ketone or the aldehyde or the amine thereto, either all at once or in metered amounts.

The hydrogenation can be carried out continuously or batchwise in various types of reactor. Preference is given to those reactors which allow comparatively good intermixing and good removal of heat, such as, for example, loop reactors. That type of reactor has proved to be especially satisfactory when small amounts of catalyst are used.

The process according to the invention yields the corresponding amines in short reaction times while having high chemical conversion rates, with surprisingly good optical yields (ee) of 70 % or more being obtained even at relatively high temperatures of more than 50°C, and even with high molar ratios of imine to catalyst.

The hydrogenated organic compounds that can be prepared in accordance with the invention, for example the amines, are biologically active substances or are intermediates for the preparation of such substances, especially in the field of the preparation of pharma¬ ceuticals and agrochemicals. For example, o,o-dialkylarylketamine derivatives, especially those having alkyl and/or alkoxyalkyl groups, are effective as fungicides, especially as herbicides. The derivatives may be amine salts, acid amides, for example of chloroacetic acid, tertiary amines and ammonium salts (see, for example, EP-A-0077755 and EP-A-0 115 470).

Especially important in this connection are the optically active amines of formula VI

which can be prepared from the imines of formula (V) in the presence of asymmetric iridium catalysts using the processes according to the invention and in which R _Q ,, R _O2 and Ro ₃ are each independently of the others Q-Qalkyl, and R _Q4 is Q-Qalkyl or Q-Qalkoxymethyl or Q-Qalkoxyethyl, and especially the amines of the formulae

which can be prepared from the imines of formulae (Va) and (Vb) and which can be converted in accordance with methods that are customary per se with chloroacetic acid into the desired herbicides of the chloroacetanilide type; of those compounds, special preference is given to those having the S-configuration at the asymmetric C* atom.

The Examples that follow illustrate the invention in more detail. The chemical conversion is determined by gas chromatography [column: 2 m OV 100/100 to 200°C at 10°C/min]. The optical yields (enantiomeric excess, ee) are determined either by gas chromatography [Chirasil-Val column, 50 m, manufacmrer: Alltech, USA, T = 150°C, isothermic], by HPLC (Chiracel OD column) or by ^** H-NMR spectroscopy (using shift reagents).

Examples 1 to 6 and Comparison Example:

20.5 g (100 mmol) of N-(2'-methyl-6'-ethyl-phen-l ^, -yl)-N-(l-methoxymethyl)eth-l-yl- ideneamine (purity 99.3 %) are placed as the initial batch in a 50 ml microautoclave. Then 100 mg of a solid acid and a mixture of 0.15 mg (0.00045 mmol) of [Ir(l,5-cycloocta- diene)Cl] ₂ , 0.35 mg of [(R)-l-[(S)-2-(diphenylphosphino)-ferrocenyl]]ethyl-di(3,5-d i- methylphenyl)phosphine and 4.5 mg (0.03 mmol) of sodium iodide are added. The auto¬ clave is closed and, with stirring (1000 rev/min), flushed three times with argon. The stirring device is stopped and the flushing operation is repeated with hydrogen. Then the hydrogen pressure is increased to 100 bar and the autoclave is closed. The stirring device is switched on again (1400 to 1500 rev/min) and the autoclave is heated to 50°C. After 1, 2 and 3 hours, the stirring device is switched off, the autoclave is depressurised and 0.5 ml of the reaction mixture is removed using a syringe. The autoclave is then closed again and flushed three times with argon and a hydrogen pressure of 100 bar is applied. The enantioselectivity in the final sample (after 3 hours) is 76 to 77 % ee (S-form). The results are summarised in Table 1 below:

Table 1

Example No. Acid Conversion lh 2h 3h

Comparison none 14

Example

1 ZrO ₂ (gel) 55 83 95

2 SiO ₂ /ZrO ₂ (gel) 28 35 42

3 HgPW^O^o 45 68 78

4 SiO ₂ , impregnated 58 83 98 with 2N H ₂ SO ₄

5 Zeolith Y impregnated 59 89 99 with 2N H ₂ SO ₄

6 Montmorillonit KSF 62 90 98 impregnated with

2N H ₂ SO ₄