PROCESS FOR LOTILANER INTERMEDIATE

Title:

PROCESS FOR LOTILANER INTERMEDIATE

Document Type and Number:

WIPO Patent Application WO/2022/016490

Kind Code:

A1

Abstract:

The present invention provides processes for making enatiomerically pure lotilaner characterized by improving the enantiomeric purity of 3-methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]thiophene-2-carboxylic acid by crystallization.

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Inventors:

CHEN JING (US)
ZHANG XIN (US)
HUANG PING (US)

Application Number:

PCT/CN2020/104035

Publication Date:

January 27, 2022

Filing Date:

July 24, 2020

Export Citation:

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Assignee:

ELANCO US INC (US)
ELANCO SHANGHAI ANIMAL HEALTH CO LTD (CN)

International Classes:

C07D413/04

Domestic Patent References:

WO2014090918A1

2014-06-19

Foreign References:

CN110028462A	2019-07-19
CN109328017A	2019-02-12
CN107074835A	2017-08-18

Attorney, Agent or Firm:

CHINA PATENT AGENT (H.K.) LTD. (CN)

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