PROCESS FOR MAKING HIV PROTEASE INHIBITORS

Title:

PROCESS FOR MAKING HIV PROTEASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO1995002584

Kind Code:

A3

Abstract:

Intermediates of structural formula can be made by reacting glycidol or an activated derivative thereof with an amide. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.

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Inventors:

ASKIN DAVID
VOLANTE RALPH P
ENG KAN K

Application Number:

PCT/US1994/007706

Publication Date:

March 09, 1995

Filing Date:

July 11, 1994

Export Citation:

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Assignee:

MERCK & CO INC (US)

International Classes:

C07D241/14; C07D241/04; C07D263/52; C07D413/06; (IPC1-7): C07D263/52

Foreign References:

US5169952A	1992-12-08
EP0480714A2	1992-04-15
EP0521686A1	1993-01-07

Other References:

D. ASKIN ET AL.: "Highly Diastereoselective Alkylations of Chiral Amide Enolates: New Routes to Hydroxyethylene Dipeptide Isostere Inhibitors of HIV-1 Protease", J. ORG. CHEM., vol. 57, no. 10, 1992, pages 2771 - 2773
B.D. DORSEY ET AL.: "A Concise and Enantioselective Synthesis of Novel HIV-1 Protease Transition state Mimics", TETRAHEDRON LETTERS, vol. 34, no. 12, 1993, pages 1851 - 1854

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