A Process for manufacturing an herbal composition for curing Psoriasis and herbal composition made thereof

Field Of Invention:

The present invention relates to process for manufacturing an herbal composition for curing Psoriasis. Also it relates to an herbal composition manufactured by the aforesaid process.

Prior Art:

Psoriasis is a skin disorder that includes the presence of small elevations of the skin that may be characterized as elevated red lesions, plaques or pustules on the skin which eventually result in silvery scales. These silvery scales and plaque are the result of accelerated epidermal proliferation and the metabolic activity and proliferation of capillaries in the dermal region and the invasion of the dermis and epidermis by inflammatory cells. More specifically, the capillaries in the dermal region become tortuous and dilated as well as suffering an inflammatory reaction causing the skin to redden.

The exact mechanism which triggers the abnormal cell prolif eration is not known, though it is believed there may be biochemical stimuli and environmental factors. The severity and course of psoriasis can vary greatly depending on the individual, but in general this chronic skin condition recurs throughout the lif e of the individual with varying intervals of one month to many years.

Over the years a wide variety of methods of treatment for psoriasis, both topical and systemic, which inhibit the cell division have been developed. In general, these methods have met with limited short term success and are not very well understood. As the disease requires treating the individual intermittently during their lifetime,

treatment risk increases with treatment length since common medicaments evidence cumulative long term side effects.

Historically, psoriasis has been treated topically with coal tar derivatives as well as salicylic acid with limited success. Corticosteroids and other similar drugs have been found effective for serious cases of psoriasis. Unfortunately many of these drugs produce serious side effects, and in some cases once the drugs are discontinued, the psoriasis recurs with marked exacerbation. Other forms of treatment include folic acid antagonists, ionizing radiation therapy, a variety of combinations of ointments and polyethylene films, sunlight and ultraviolet baths.

Prior art psoriasis medications and methods of medical treatment have been devised to address the aforenoted problems. For example, U.S. Pat. No. 5,425,954 issued on Jun. 20, 1995 to Thompson et al. and provides for a composition for topical application to the skin, comprising a mixture of Panthenol (B.sub.5), Cod Liver Oil, Alpha Tocopherol Acetate, Arginine, Isoleucine, Leucine, Methionine, Phenylalanine, Threonine, and Valine in admixture with a suitable carrier.

U.S. Pat. No. 5,990,100 issued on Nov. 23, 1999 to Rosenbert et al. and this patent relates to pharmaceutical compositions and methods for use in the treatment of psoriasis, having isopropyl myristate as a first active ingredient and a different anti- psoriatic agent as a second active ingredient; preferably they are combined in the same pharmaceutical composition.

U.S. Pat. No. 4,981,681 issued on Jan. 1, 1991 to Tosti and relates to a method for treating psoriasis and more particularly it relates to a method of treating psoriasis by systematic and periodic application of several selected ingredients including the active ingredient Salicylic Acid.

U.S. Pat. No. 5,886,038 issued on Mar. 23, 1999 to Glenn et al. and relates to a pharmaceutical composition for use in the treatment of psoriasis, having isopropyl myristate as its only active ingredient.

U.S. Pat. No. 5,165,932 issued on Nov. 24, 1992 to Horvath and relates to therapeutical compositions on medical herb basis for the treatment of psoriasis and the preparation of the same. The medical herbs used in the invention are Allium, sativum/ garlic/, Urtica dioica/ common nettle/, Chelidonium majus/mϋkweed/, Veronica officinalis /veronica/, Calendula officinalis/ calendula or marigold/, Achillea herba/ millefolium/ yarrow/ and Fumaria officinalis/fumitory, earth-gall.

The conventional Herbal formulations, which are available, are not found effective for curing the above diseases. Also they all having up to some extent the risk of side effects. Therefore, there is a need to have different combination in full therapeutic effect of the active ingredients present in the different types of Herbs to give synergy effect with minimal or no side effect. Thus a composition of treatment for psoriasis which allows for the successful treatment by reducing the frequency of the recurrence of the psoriasis is desirable.

Object of Invention:

The main object of the present invention is to provide a process for manufacturing an herbal composition for curing Psoriasis.

Further object of present invention is to provide an herbal composition manufactured by the aforesaid mentioned process.

Another object is to provide herbal medicament for curing Psoriasis with least or no side effect.

Another object is to provide herbal medicament for curing Psoriasis in a shorter span of time.

Accordingly there is provided a process for manufacturing a herbal composition comprises the steps of:

a. selecting the extracts of the following Herbs in the given percentage by weight:

1. 13 % by weight fruit extract of Ritha (Sapindus trifoliatus)

2. 18% by weight leaf extract of Medasinghi (Gymnema sylvastre)

3. 12% by weight fruit & seed extract of AmIa (Phyllanthus emblica)

4. 10% by weight leaf extract of Kalmegh (Andrographis paniculata)

5. 3% by weight root extract of Veeranmool (Andropogan muricatus)

6. 5% by weight leaf extract of Kalyani (Cassia obovata)

7. 10% by weight stem and leaf extract of Wonga (Achyrantus aspera)

8. 12% by weight stem and leaf extract of Bhangra (Eclipta prostrata)

9. 12% by weight root extract of Haldi (Curcuma longa)

10. 5% by weight root extract of Aswagandha (Withania somnifera)

wherein aforesaid mentioned herbal extracts are cultivated in red soil and harvested in non-sunlight after the maturity period and cut in non-sunlight in a hygienic condition probably on clean stone for hygienic purpose and dried in sunlight before grinding for one to two days;

a. grinding the above Herbs separately in a grinder at a speed of 1500 rpm;

b. pulverizing/blending the ingredients in their specific proportion as given above in a pulverizer/ blender run at a speed of 500 rpm for 30 to 60 minutes;

c. sieving the mixed powder through a sieve made of nylon cloth of 150 mesh size.

Also there is provided an herbal composition comprises:

1. 13 % by weight fruit extract of Ritha (Sapindus trifoliatus)

2. 18% by weight leaf extract of Medasinghi (Gymnema sylvastre)

3. 12% by weight fruit & seed extract of AmIa (Phyllanthus emblica)

4. 10% by weight leaf extract of Kalmegh (Andrographis paniculata)

5. 3% by weight root extract of Veeranmool (Andropogan muricatus)

6. 5% by weight leaf extract of Kalyani (Cassia obovata)

7. 10% by weight stem and leaf extract of Wonga (Achyrantus aspera)

8. 12% by weight stem and leaf extract of Bhangra (Eclipta prostrata)

9. 12% by weight root extract of Haldi (Curcuma longa)

10. 5% by weight root extract of Aswagandha (Wϊthania somnifera)

Detailed description of the invention:

Now following description will explain the invention in details.

The herbal composition of the present invention essentially comprising of following main ingredients:

1. SAPINDUS TRIFOLIATUS

Common Name : Ritha

It is used to get relief from headache by applying it to the forehead. It is also used to cure asthma, epitasis, eye diseases and other yawns. This soap nut powder is used for shampooing to reduce overheat in the body, skin allergies.

2. GYMNEMA SYLVESTRE

Common Name : Medasinghi

It is effective for curing leprosy, ulcers, itches, scabies and all skin diseases. It also cures pain and asthma. The leaves extract will be used to all type of skin diseases. It heals wounds on the body very fast if you apply their leaves on the wounds.

3. PHYLLANTHUS EMBLICA

Common Name : AmIa

It is best for removing scabies, skin diseases and pains.

4. ANDROGRAPHIS PANICULATA

Common Name : Kalmegh

It cures ulcers, cough, phlegm, anemia and headache. It gives strength to stomach, increase semen & cures all kidney diseases. It also cures fever and cold diseases.

5. ANDROPOGAN MURICATUS

Common Name : Veeranmool

It is used to kill inflammation, diarrhea, leucorrhea, excessive bile, delusion, haematemesis, T.B, rheumatic fever etc.

6. CASSIA OBOVATA

Common Name : Kalyani

This ingredient is used for bathing. All black spots on skin will disappear. It acts against dandruff and keeps you free from dandruff when used for shampooing. It gives strength to your hair by keeping it black. It is peculiar in curing diabetes.

7. ACHYRANTUS ASPERA

Common Name : Wonga

This ingredient cures all types of leprosy, itches, eczema, boils and skin diseases.

8. ECLIPTA PROSTRATA

Common Name : Bhangra

It cures leprosy, itches, cough, fever, asthma, phlema and anemia. It is good for eyes. It keeps your hair black. It gives strength to your body. It is also useful to cure Elephantiasis. It relieves pain like body-ache, headache etc. It is also cures liver & spleen diseases.

9. CURCUMA LONGA

Common Name : Haldi

It purifies blood and for digestive system. It cures itching and bacterial diseases.

10. WITHANIA SOMNIFERA

Common Name : Aswagandha

This cures T.B, Phlegm, Fistula and many other diseases. This is good for health. It gives strength and complexion. This is useful in developing your muscles. It also cures cough, leprosy, esnofilia. It gives strength to waist. It gives strength to nerves. It also cures joint pains.

Above mentioned herbs are naturally occurring and cultivated through out India most preferably in Andhra Pradesh in forest. The selection of these herbs from the region as well as the climatic condition, soil, manure of all this have effects on the raw material used.

According to the present invention an herbal composition comprises the following ingredients in proper amount:

1. 13 % by weight fruit extract of Ritha (Sapindus trifoliatus)

2. 18% by weight leaf extract of Medasinghi (Gymnema sylvastre)

3. 12% by weight fruit & seed extract of AmIa (Phyllanthus emblica)

4. 10% by weight leaf extract of Kalmegh (Andrographis paniculata)

5. 3 % by weight root extract of Veeranmool (Andropogan muricatus)

6. 5 % by weight leaf extract of Kalyani (Cassia obovata)

7. 10% by weight stem and leaf extract of Wonga (Achyrantus aspera)

8. 12% by weight stem and leaf extract of Bhangra (Eclipta prostrata)

9. 12% by weight root extract of Haldi (Curcuma longa)

10. 5% by weight root extract of Aswagandha (Withania somnifera)

Then according to process of the present invention above mentioned herbs are ground separately in a grinder at a speed of 1500 rpm. Then these are pulverized/blended in their specific proportion as given above in a pulverizer/blender run at a speed of 500 rpm for 30 to 60 minutes. Then the mixed powder is sieved through a sieve made of nylon cloth of 150 mesh size.

The formulations of the present invention are not a mere admixture resulting in mere aggregation of the properties of individual ingredients but in a synergistic mixture resulting in enhanced curative properties. Also the clinical trial has been conducted on this newly developed herbal composition and it is surprisingly found that efficacy is improved by using this formulation instead of using individual ingredients of the formulation. Also the clinical trials have been conducted on the patients suffering from the Psoriasis. All have applied the formulation of the present invention on their skin externally once or twice a day depending on the extent of Psoriasis and it has been found that patients get cured in a shorter span of time with least or no side effects. Extent of side effect is varying from person to person. No severe side effect is found.

Example:

The example tells about only the best method of performing the invention. Hence it is considered only for illustration purpose and not for limiting the scope of invention.

Firstly the herbs are selected and cultivated in the red soil using bio-fertilizer manure or all natural waste. These are harvested in Non-sunlight after the maturity period and cut after 10 or 12 days in a non-sunlight or shed with hygienic condition preferably on stone. Subsequently dried in sunlight for 1 to 2 days. Then extracts of above herbs in following percentage by weight are selected:

1. 13 % by weight fruit extract of Ritha (Sapindus trifoliatus)

2. 18% by weight leaf extract of Medasinghi (Gymnema sylvastre)

3. 12% by weight fruit & seed extract of AmIa (Phyllanthus emblica)

4. 10% by weight leaf extract of Kalmegh (Andrographis paniculata)

5. 3% by weight root extract of Veeranmool (Andropogan muricatus)

6. 5% by weight leaf extract of Kalyani (Cassia obovata)

7. 10% by weight stem and leaf extract of Wonga (Achyrantus aspera)

8. 12% by weight stem and leaf extract of Bhangra (Eclipta prostrata)

9. 12% by weight root extract of Haldi (Curcuma longa)

10. 5 % by weight root extract of Aswagandha (Withania somnif era)

Then herb extract are grinded separately in a grinder with 1500 rpm to make powder form and pulverized/blended in the specific proportion as given above in the pulverizer/blender for thorough mixing with speed of 500 rpm for 45 minutes. Then resultant mixture sieved through the nylon cloth of 150 mesh size to obtain the required particle size of the active ingredients which. The formulation of the present invention is available in powdered form.

However, it should be understood that the invention is not limited in this regard, and the relative amounts of these ingredients can be varied to achieve similar results.

Industrial Applicability

The invention provides herbal composition for curing Psoriasis which is very well used in the medicinal field and drug industries.