Title:
PROCESS FOR OBTAINING FUNCTIONAL LYMPHOCYTES CELLS
Document Type and Number:
WIPO Patent Application WO/2023/242398
Kind Code:
A1
Abstract:
The invention relates to the use of a composition comprising the following compounds: Activin A, BMP4, CHIR99, EGF, FGF 8, FGF 10, IGF1, LY3, Noggin, retinoic acid and Y27, for implementing a differentiation process, preferably in vitro or ex vivo, of an induced pluripotent stem cell or iPSc, into a functional thymic epithelial progenitor or TEP.
Inventors:
PROVIN NATHAN (FR)
GIRAUD MATTHIEU (FR)
GIRAUD MATTHIEU (FR)
Application Number:
PCT/EP2023/066229
Publication Date:
December 21, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
UNIV NANTES (FR)
INST NAT SANTE RECH MED (FR)
INST NAT SANTE RECH MED (FR)
International Classes:
C12N5/078
Domestic Patent References:
| WO2020220040A1 | 2020-10-29 | |||
| WO2020205859A1 | 2020-10-08 | |||
| WO2020205859A1 | 2020-10-08 | |||
| WO2020220040A1 | 2020-10-29 |
Other References:
GRAS-PEÑA RAFAEL ET AL: "Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 149, no. 5, 22 October 2021 (2021-10-22), pages 1755 - 1771, XP087044952, ISSN: 0091-6749, [retrieved on 20211022], DOI: 10.1016/J.JACI.2021.09.038
CAS, no. 129830-38-2
CAS, no. 129830-38-2
Attorney, Agent or Firm:
MONNI, Richard et al. (FR)
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