Title:
PROCESS FOR PREPARATION OF ALKYLENE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2002/088072
Kind Code:
A1
Abstract:
The invention provides an industrially advantageous process for preparation of 3-methoxydecanol derivatives, specifically a process for preparation of compounds represented by the general formula (5), salts thereof, or hydrates of both, characterized by protecting the hydroxyl group of a compound represented by the general formula (4): (5) wherein R is C1-6 alkyl; and PG?2¿ is a hydroxyl-protecting group.
Inventors:
SASYOU MANABU (JP)
NAITO TOSHIHIKO (JP)
NAITO TOSHIHIKO (JP)
Application Number:
PCT/JP2002/003984
Publication Date:
November 07, 2002
Filing Date:
April 22, 2002
Export Citation:
Assignee:
EISAI CO LTD (JP)
SASYOU MANABU (JP)
NAITO TOSHIHIKO (JP)
SASYOU MANABU (JP)
NAITO TOSHIHIKO (JP)
International Classes:
C07C303/28; C07C309/66; (IPC1-7): C07C303/28; C07C41/20; C07C41/30; C07C43/13; C07C43/178; C07C309/66
Domestic Patent References:
| WO1996039411A1 | 1996-12-12 |
Foreign References:
| US5935938A | 1999-08-10 |
Other References:
OOI TAKASHI ET AL.: "Remarkable catalytic activity of Me3Ga in the alkylation of hetero-substituted epoxides with alkynyl-lithiums", TETRAHEDRON LETTERS, vol. 40, no. 32, 1999, pages 5881 - 5884, XP004172318
GUO JIASHENG ET AL.: "Total synthesis of altohyrtin A (spongistatin 1): part 1", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 37, no. 1/2, 1998, pages 187 - 192, XP002131642
JAKOB BARBARA ET AL.: "Synthesis of (S)- and (R)-3-hydroxy-hexadecanoic acid", TETRAHEDRON: ASYMMETRY, vol. 7, no. 11, 1996, pages 3255 - 3262, XP002955608
GUO JIASHENG ET AL.: "Total synthesis of altohyrtin A (spongistatin 1): part 1", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 37, no. 1/2, 1998, pages 187 - 192, XP002131642
JAKOB BARBARA ET AL.: "Synthesis of (S)- and (R)-3-hydroxy-hexadecanoic acid", TETRAHEDRON: ASYMMETRY, vol. 7, no. 11, 1996, pages 3255 - 3262, XP002955608
Attorney, Agent or Firm:
Inami, Minoru (INABA & INAMI Hanabishi Imas Hirakawacho
Building, 4th Floor, 3-11, Hirakawacho 2-chom, Chiyoda-ku Tokyo, JP)
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