Title:
A PROCESS FOR THE PREPARATION OF CILASTATIN SODIUM
Document Type and Number:
WIPO Patent Application WO/2008/138228
Kind Code:
A1
Abstract:
The invention provides a process for the preparation of cilastatin sodium which comprises purifying (Z)-7-chloro-2-((S)-2,2-dimethylcyclopropylcarboxamide)-2-heptenoic acid by crystallization to prepare cilastatin and purifying cilastatin using neutral macroporous resin to prepare cilastatin sodium, thereby improving the purity and yield of cilastatin sodium.
Inventors:
LU ZHAOQIANG (CN)
ZHANG HENGLI (CN)
ZHANG HENGLI (CN)
Application Number:
PCT/CN2008/000947
Publication Date:
November 20, 2008
Filing Date:
May 15, 2008
Export Citation:
Assignee:
SHENZHEN HAIBIN PHARMACEUTICAL (CN)
LU ZHAOQIANG (CN)
ZHANG HENGLI (CN)
LU ZHAOQIANG (CN)
ZHANG HENGLI (CN)
International Classes:
C07C319/14; C07C323/59
Domestic Patent References:
| WO2006022511A1 | 2006-03-02 |
Foreign References:
| CN1592737A | 2005-03-09 | |||
| EP0048301A1 | 1982-03-31 |
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (Tower B of IN.DO Mansion No. 48-Jia Zhichun Road, Haidian District, Beijing 8, CN)
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