Title:
PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE AND POLYMORPHS OF INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/111163
Kind Code:
A3
Abstract:
The present invention provides crystalline form of intermediates of Formula 2A, Formula 2B and Formula E. The present invention also provides process for the preparation of dabigatran etexilate mesylate; polymorph of intermediates thereof; particularly processes for the preparation of crystalline form of intermediates. The present invention also relates to the use of crystalline intermediates for the preparation of dabigatran etexilate mesylate.
Inventors:
DWIVEDI SHRIPRAKASH DHAR (IN)
SINGH RAMESH CHANDRA (IN)
RAVAL JIGAR MUKUNDBHAI (IN)
SINGH RAMESH CHANDRA (IN)
RAVAL JIGAR MUKUNDBHAI (IN)
Application Number:
PCT/IN2013/000037
Publication Date:
October 10, 2013
Filing Date:
January 21, 2013
Export Citation:
Assignee:
CADILA HEALTHCARE LTD (IN)
International Classes:
C07D213/75; C07D401/12
Domestic Patent References:
| WO2009153214A1 | 2009-12-23 | |||
| WO1998037075A1 | 1998-08-27 | |||
| WO2007071742A1 | 2007-06-28 | |||
| WO2012004396A2 | 2012-01-12 |
Other References:
HAUEL N H ET AL: "STRUCTURE-BASED DESIGN OF NOVEL POTENT NONPEPTIDE THROMBIN INHIBITORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 45, no. 9, 26 March 2002 (2002-03-26), pages 1757 - 1766, XP001098844, ISSN: 0022-2623, DOI: 10.1021/JM0109513
Attorney, Agent or Firm:
MAHLA, Aaysu et al. (Nataraj & AssociatesE- 556, Greater Kailash-II, New Delhi 8, IN)
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