Title:
PROCESS FOR THE PREPARATION OF DASATINIB AND ITS INTERMEDIATES
Document Type and Number:
WIPO Patent Application WO/2014/102759
Kind Code:
A3
Abstract:
The present invention relates to processes for the preparation of dasatinib and its intermediates.
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Inventors:
JARYAL JAGDEV SINGH (IN)
KAPOOR MUNISH (IN)
SATHYANARAYANA SWARGAM (IN)
THAPER RAJESH KUMAR (IN)
PRASAD MOHAN (IN)
KAPOOR MUNISH (IN)
SATHYANARAYANA SWARGAM (IN)
THAPER RAJESH KUMAR (IN)
PRASAD MOHAN (IN)
Application Number:
PCT/IB2013/061453
Publication Date:
October 30, 2014
Filing Date:
December 31, 2013
Export Citation:
Assignee:
RANBAXY LAB LTD (IN)
International Classes:
C07D417/12; C07D277/56
Foreign References:
| US20050261305A1 | 2005-11-24 |
Other References:
DATABASE WPI [online] THOMSON SCIENTIFIC, LONDON, GB; 11 August 2011 (2011-08-11), HOU W. ET AL: "Manufacture of dasatinib involves acyl chlorinating chlorine-containing compound, reacting obtained compound with 2-chloro-6-methylaniline, and reacting resultant compound with 1-(2-hydroxyethyl)piperazine", XP002719886, accession no. 2011-K18594 Database accession no. 2011-K18594
ZERONG WANG: "COMPREHENSIVE ORGANIC NAME REACTIONS AND REAGENTS", 15 September 2010, JOHN WILEY & SONS, INC., Hoboken, NJ, ISBN: 0470533463, article "96 Bodroux Amide Synthesis", pages: 445 - 447, XP055100696, DOI: http://onlinelibrary.wiley.com/doi/10.1002/9780470638859.conrr096/pdf
JUAN DE M. MUÑOZ ET AL: "Preparation of amides mediated by isopropylmagnesium chloride under continuous flow conditions", GREEN CHEMISTRY, vol. 14, no. 5, 1 January 2012 (2012-01-01), pages 1335, XP055100589, ISSN: 1463-9262, DOI: 10.1039/c2gc35037h
ZERONG WANG: "COMPREHENSIVE ORGANIC NAME REACTIONS AND REAGENTS", 15 September 2010, JOHN WILEY & SONS, INC., Hoboken, NJ, ISBN: 0470533463, article "96 Bodroux Amide Synthesis", pages: 445 - 447, XP055100696, DOI: http://onlinelibrary.wiley.com/doi/10.1002/9780470638859.conrr096/pdf
JUAN DE M. MUÑOZ ET AL: "Preparation of amides mediated by isopropylmagnesium chloride under continuous flow conditions", GREEN CHEMISTRY, vol. 14, no. 5, 1 January 2012 (2012-01-01), pages 1335, XP055100589, ISSN: 1463-9262, DOI: 10.1039/c2gc35037h
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