PROCESS FOR PREPARATION OF ELIGLUSTAT HEMITARTRATE AND INTERMEDIATES THEREOF

Title:

PROCESS FOR PREPARATION OF ELIGLUSTAT HEMITARTRATE AND INTERMEDIATES THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/193090

Kind Code:

A3

Abstract:

Process for preparation of eliglustat hemitartrate and intermediates thereof Processes for preparation of eliglustat hemitartrate and intermediates thereof are provided. A stable amorphous form of eliglustat hemitartrate pharmaceutical compositions including the amorphous form of eliglustat hemitartrate, and their uses are also provided.

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Inventors:

KUMAWAT KANARAM HANUMANPRASAD (IN)
PATEL BRIJESH RAJENDRAKUMAR (IN)
THUMAR NILESH MANSUKHLAL (IN)
UPADHYAY JOSEPH PRABAHAR (IN)
KOILPILLAI JOSEPH PRABAHAR (IN)
AGARWAL VIRENDRAKUMAR (IN)
PUROHIT PARVA YOGESHCHANDRA (IN)
SIDDIQUI ARIF BADRULHUSAN (IN)
PATEL KRUSHNAKANT NATVARBHAI (IN)
GONDALIYA VIPUL VELJIBHAI (IN)
BUHA ANKIT RAMJIBHAI (IN)

Application Number:

PCT/EP2018/060185

Publication Date:

January 03, 2019

Filing Date:

April 20, 2018

Export Citation:

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Assignee:

AMNEAL PHARMACEUTICALS COMPANY GMBH (CH)

International Classes:

C07D319/18

Domestic Patent References:

WO2011066352A1	2011-06-03
WO2004101558A1	2004-11-25

Foreign References:

US7615753B2

2009-11-10

Other References:

"/1 -(C) FILE REGISTRY RN -2138286-91-4 REGISTRY ED -Entered STN: 02 Nov 2017 CN -Octanamide, N-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxo-1-(1- pyrrolidinylmethyl)ethyl]-(CA INDEX NAME) MF -C23 H34 N2 O4 SR -Chemical Catalog Supplier: Enamine LLC LC -STN Files: CHEMCATS", 2 November 2017, article CHEMICAL ABSTRACTS OHIO: "/1 -(C) FILE REGISTRY RN -2138286-91-4 REGISTRY ED -Entered STN: 02 Nov 2017 CN -Octanamide, N-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxo-1-(1- pyrrolidinylmethyl)ethyl]-(CA INDEX NAME) MF -C23 H34 N2 O4 SR -Chemical Catalog Supplier: Enamine LLC LC -STN Files: CHEMCATS", XP055491732

Attorney, Agent or Firm:

FRKELLY (IE)

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