Title:
PROCESS FOR THE PREPARATION OF THE ENANTIOMERIC FORMS OF 2-SUBSTITUTED 2-(2,5-DIOXOIMIDAZOLIDIN-1-YL)-ACETIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2003008386
Kind Code:
A3
Abstract:
The present invention relates to a process for the preparation of the enantiomeric forms of 2-substituted 2-(2,5-dioxoimidazolidin-1-yl)acetic acid derivatives of the formula I, wherein R<1>, R<2> and R<3> have the meanings given in the claims, by stereodifferentiating conversion of mixtures of the enantiomers with the aid of enzymes.
Inventors:
HOLLA WOLFGANG
Application Number:
PCT/EP2002/007560
Publication Date:
November 18, 2004
Filing Date:
July 06, 2002
Export Citation:
Assignee:
AVENTIS PHARMA GMBH (DE)
International Classes:
C12P41/00; C07D233/72; C07D233/74; (IPC1-7): C07D233/74
Domestic Patent References:
| WO2000069831A1 | 2000-11-23 |
Foreign References:
| EP0149674A1 | 1985-07-31 |
Other References:
ROBERTI M ET AL: "Pig liver esterase (PLE)-mediated resolution of N-substituted 4-benzoyloxy-3-carbomethoxypiperidines: a convenient preparation of 4-hydroxy- and 4-benzoyloxy-3-carbomethoxypiperidines in enantiomerically pure form", TETRAHEDRON: ASYMMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 11, no. 21, 3 November 2000 (2000-11-03), pages 4397 - 4405, XP004225306, ISSN: 0957-4166
MAMAGHANI M: "Enzymatic kinetic resolution of aromatic substituted norbornene mono-esters using pig's liver esterase", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 58, no. 1, 1 January 2002 (2002-01-01), pages 147 - 151, XP004313485, ISSN: 0040-4020
MAMAGHANI M: "Enzymatic kinetic resolution of aromatic substituted norbornene mono-esters using pig's liver esterase", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 58, no. 1, 1 January 2002 (2002-01-01), pages 147 - 151, XP004313485, ISSN: 0040-4020
Download PDF: