Title:
PROCESS FOR THE PREPARATION OF GALETERONE
Document Type and Number:
WIPO Patent Application WO/2017/208132
Kind Code:
A1
Abstract:
A process for the synthesis of 3β-hydroxy-17-(1H-benzimidazol-1-yl)androsta-5,16-diene is described, a compound also known as Galeterone and used in the treatment of prostate cancer, having the formula (I) given below.
Inventors:
BARBIERI FRANCESCO (IT)
LENNA ROBERTO (IT)
LENNA ROBERTO (IT)
Application Number:
PCT/IB2017/053147
Publication Date:
December 07, 2017
Filing Date:
May 29, 2017
Export Citation:
Assignee:
IND CHIMICA SRL (IT)
International Classes:
C07J43/00; C07J75/00
Domestic Patent References:
| WO2010091306A1 | 2010-08-12 |
Foreign References:
| US20110034428A1 | 2011-02-10 |
Other References:
HANDRATTA VENKATESH D ET AL: "Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 48, no. 8, 25 March 2005 (2005-03-25), pages 2972 - 2984, XP002535274, ISSN: 0022-2623, DOI: 10.1021/JM040202W
ANDERSON ET AL: "TOOLS FOR PURIFYING THE PRODUCT: COLUMN CHROMATOGRAPHY, CRYSTALLIZATION AND RESLURRYING", PRACTICAL PROCESS RESEARCH AND DEVELOPMENT, ACADEMIC PRESS, SAN DIEGO, US, 1 January 2000 (2000-01-01), pages 223 - 247, XP002382432
ANDERSON ET AL: "TOOLS FOR PURIFYING THE PRODUCT: COLUMN CHROMATOGRAPHY, CRYSTALLIZATION AND RESLURRYING", PRACTICAL PROCESS RESEARCH AND DEVELOPMENT, ACADEMIC PRESS, SAN DIEGO, US, 1 January 2000 (2000-01-01), pages 223 - 247, XP002382432
Attorney, Agent or Firm:
PALLADINO, Massimo et al. (IT)
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