Title:
PROCESS FOR THE PREPARATION OF GRIGNARD COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2010/117285
Kind Code:
A3
Abstract:
The invention relates to a process for the preparation of Grignard compounds using a continuous method which involves the reaction of an organic halide dissolved in an organic solvent with metallic magnesium which, together with the activator solution in an organic solvent, fills the flow reactor or optionally a system of flow reactors, and subsequently, the resulting reaction mixture is fed into the terminal flow reactor containing metallic magnesium in order to achieve complete conversion of the organic halide, whereby preferably the organic solvent is re-circulated to flow reactors in a form of vapour.
Inventors:
SZEJA WIESLAW (PL)
HELMAN JAN (PL)
KIRAGA KRZYSZTOF (PL)
DERFLA SEBASTIAN (PL)
HELMAN JAN (PL)
KIRAGA KRZYSZTOF (PL)
DERFLA SEBASTIAN (PL)
Application Number:
PCT/PL2010/000024
Publication Date:
December 02, 2010
Filing Date:
March 29, 2010
Export Citation:
Assignee:
ZAKLADY FARMACEUTYCZNE POLPHARMA SA (PL)
SZEJA WIESLAW (PL)
HELMAN JAN (PL)
KIRAGA KRZYSZTOF (PL)
DERFLA SEBASTIAN (PL)
SZEJA WIESLAW (PL)
HELMAN JAN (PL)
KIRAGA KRZYSZTOF (PL)
DERFLA SEBASTIAN (PL)
International Classes:
C07F3/02
Foreign References:
| US3911037A | 1975-10-07 | |||
| US2464685A | 1949-03-15 |
Other References:
JENNINGS ET AL: "A novel, continuous high-yield synthesis of Grignard reagents", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER-SEQUOIA S.A. LAUSANNE, CH LNKD- DOI:10.1016/0022-328X(87)80384-4, vol. 325, no. 1-2, 12 May 1987 (1987-05-12), pages 25 - 29, XP026611033, ISSN: 0022-328X, [retrieved on 19870512]
Attorney, Agent or Firm:
MATYKA, Malgorzata (ul. Pelplinska 19, 83-200 Starogard Gdanski, PL)
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