Title:
PROCESS FOR PREPARATION OF INTERMEDIATES OF BENDAMUSTINE
Document Type and Number:
WIPO Patent Application WO/2012/007966
Kind Code:
A3
Abstract:
The present invention relates to a process for the preparation of 4-{5-{ Bis-(2-hydroxyl-ethyl)-amino}-1-methyl-1H-Benzoimidazol-2yl}-butyric acid alkyl ester of formula IV, a key intermediate in the process for the preparation of Bendamustine HCI (I)
Inventors:
PULLAGURLA MANIK REDDY (IN)
RANGISETTY JAGADEESH BABU (IN)
PRESLEY S I DAVIS (IN)
NAGARAPU RADHA (IN)
RANGISETTY JAGADEESH BABU (IN)
PRESLEY S I DAVIS (IN)
NAGARAPU RADHA (IN)
Application Number:
PCT/IN2011/000471
Publication Date:
March 08, 2012
Filing Date:
July 14, 2011
Export Citation:
Assignee:
BIOPHORE INDIA PHARMACEUTICALS PVT LTD (IN)
PULLAGURLA MANIK REDDY (IN)
RANGISETTY JAGADEESH BABU (IN)
PRESLEY S I DAVIS (IN)
NAGARAPU RADHA (IN)
PULLAGURLA MANIK REDDY (IN)
RANGISETTY JAGADEESH BABU (IN)
PRESLEY S I DAVIS (IN)
NAGARAPU RADHA (IN)
International Classes:
C07B41/02; C07B39/00; C07D235/16
Domestic Patent References:
| WO2010042568A1 | 2010-04-15 | |||
| WO2011079193A2 | 2011-06-30 |
Other References:
"Process for preparing 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid intermediate", IP.COM JOURNAL, vol. 9, no. 7B, 2009, pages 21
GAO, LI-MEI ET AL.: "Synthesis of 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2- butanoic acid hydrochloride (Bendamustine hydrochloride)", ZHONGGUO XINYAO ZAZHI, vol. 16, no. 23, 1970, pages 1960 - 1961, XP008115772
GAO, LI-MEI ET AL.: "Synthesis of 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2- butanoic acid hydrochloride (Bendamustine hydrochloride)", ZHONGGUO XINYAO ZAZHI, vol. 16, no. 23, 1970, pages 1960 - 1961, XP008115772
Attorney, Agent or Firm:
VADEHRA, Sharad (KNK House B-483, Meera Bagh,Paschim Vihar, New Delhi 3, IN)
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