Title:
PROCESS FOR PREPARATION OF OPTICALLY ACTIVE 1-SUBSTITUTED AMINO-2,3-EPOXYPROPANES, INTERMEDIATES FOR THE SYNTHESIS THEREOF AND PROCESS FOR PREPARATION OF THE INTERMEDIATES
Document Type and Number:
WIPO Patent Application WO/2004/002973
Kind Code:
A1
Abstract:
The invention provides a process by which optically active 1-substituted amino-2,3-epoxypropanes useful as intermediates in the production of agricultural chemicals, drugs and so on can be efficiently produced with industrial advantage from optically active 1-substituted amino-2,3-propanediols, and intermediates useful in the process, specifically, a process which comprises reacting an optically active 1-substituted amino-2,3-propanediol (1) with an ortho-acid ester (2), thionyl chloride (3), or the like to form an optically active cyclic compound (4), reacting the compound (4) with a ring-opening reagent capable of introducing a halogen atom (X) to form a halogen compound (5), and finally subjecting the compound (5) to ring closure with a base to form an optically active 1-substituted amino-2,3-epoxypropane (6).
Inventors:
MATOHARA KUMI (JP)
NAGASHIMA NOBUO (JP)
NAGASHIMA NOBUO (JP)
Application Number:
PCT/JP2003/007695
Publication Date:
January 08, 2004
Filing Date:
June 17, 2003
Export Citation:
Assignee:
KANEKA CORP (JP)
MATOHARA KUMI (JP)
NAGASHIMA NOBUO (JP)
MATOHARA KUMI (JP)
NAGASHIMA NOBUO (JP)
International Classes:
C07D301/26; (IPC1-7): C07D301/26; C07D303/36; C07D327/10
Domestic Patent References:
| WO2002032857A1 | 2002-04-25 | |||
| WO1999052855A1 | 1999-10-21 | |||
| WO1999062861A1 | 1999-12-09 |
Attorney, Agent or Firm:
KANEKA CORPORATION (Kita-ku Osaka-shi, Osaka, JP)
Download PDF: