Title:
PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2003106413
Kind Code:
A3
Abstract:
A process for preparing N-(substituted)-C- (substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl) oxazolidinones is described. The process can be used to produce combinatorial libraries of the above substituted oxazolidinones in a two or three step reaction comprising a plurality of reagents differing in numbers of carbons or particular substituted oxazolidinones. A number of substituted oxazolidinones produced using the above process have been discovered to have antimicrobial activity.
Inventors:
HOLLINGSWORTH RAWLE I
WANG GUIJUN
PADMAKUMAR RAGHAVAKAIMAL
MAO JIANMIN
ZHANG HUIPING
DAI ZONGMIN
PUTHUPARAMPIL KANAKAMMA
WANG GUIJUN
PADMAKUMAR RAGHAVAKAIMAL
MAO JIANMIN
ZHANG HUIPING
DAI ZONGMIN
PUTHUPARAMPIL KANAKAMMA
Application Number:
PCT/US2002/033181
Publication Date:
October 20, 2005
Filing Date:
October 17, 2002
Export Citation:
Assignee:
UNIV MICHIGAN STATE (US)
SYNTHON CORP (US)
SYNTHON CORP (US)
International Classes:
A61K31/421; A61K31/4245; A61K31/427; A61K31/4375; A61K31/496; A61K31/5377; A61K31/7056; A61P31/04; C07B53/00; C07B61/00; C07D263/20; C07D263/24; C07D263/26; C07D413/12; C07D417/12; C07D471/04; C07H15/26; C07H17/00; C12Q1/18; C40B40/04; C40B40/12; C40B50/00; (IPC1-7): C07D413/12; C07D263/06; C07D263/24; G01N33/53; G01N33/543
Domestic Patent References:
| WO2000044717A2 | 2000-08-03 |
Foreign References:
| US6531470B1 | 2003-03-11 | |||
| US6617114B1 | 2003-09-09 | |||
| US6288238B1 | 2001-09-11 | |||
| US6288239B1 | 2001-09-11 | |||
| US5721099A | 1998-02-24 | |||
| US5545568A | 1996-08-13 |
Other References:
ALLIN S.M. ET AL: "The Preparation and First Application of a Polymer-Supported "Evans" Oxazolidinone", TETRAHEDRON LETTERS, vol. 37, no. 44, 28 October 1996 (1996-10-28), pages 8023 - 8026, XP004031033
See also references of EP 1578723A4
See also references of EP 1578723A4
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