Title:
A PROCESS FOR THE PREPARATION OF PERINDOPRIL, ITS ANALGOUS COMPOUNDS AND SALTS THEREOF USING 2,5 -DIOXO-OXAZOLIDINE INTERMEDIATE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2003010142
Kind Code:
A3
Abstract:
A process for the preparation of a compound of formula (IV), or an ester or a salt thereof comprising 1) reacting a compound of formula (I), (wherein Ra represents C1-4 alkyl, Rb represents C1-4 alkyl and Rc represents C1-6 alkyl) with a compound of formula X2C=0 (wherein each X independently represents a leaving group) to give a compound of formula (II), (wherein Ra, Rb and Rc are as hereinbefore defined); and 2) reacting said compound of formula (II) with a compound of formula (III), (wherein Rd represents hydrogen or a protecting group), compounds of formula (II), and a process for the preparation of compounds of formula (I).
Inventors:
CID PAU (ES)
Application Number:
PCT/EP2002/008223
Publication Date:
August 28, 2003
Filing Date:
July 23, 2002
Export Citation:
Assignee:
ADIR (FR)
CID PAU (ES)
CID PAU (ES)
International Classes:
C07C227/18; C07D263/44; C07K5/02; C07K5/062; C07C229/16; (IPC1-7): C07D209/42; C07D263/44
Domestic Patent References:
| WO2001056986A1 | 2001-08-09 |
Foreign References:
| US4686295A | 1987-08-11 | |||
| US5359086A | 1994-10-25 | |||
| EP0308341A1 | 1989-03-22 | |||
| EP0309324A1 | 1989-03-29 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SKILES, JERRY W. ET AL: "Syntheses of N-(carboxymethyl) dipeptides via N-carboxy.alpha.-amino acid anhydride (NCA) intermediates", XP002216969, retrieved from STN Database accession no. 109:129642
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