PROCESS FOR THE PREPARATION OF QUATERNARY N-ALKYL MORPHINAN ALKALOID SALTS

Title:

PROCESS FOR THE PREPARATION OF QUATERNARY N-ALKYL MORPHINAN ALKALOID SALTS

Document Type and Number:

WIPO Patent Application WO2004043964

Kind Code:

A3

Abstract:

A process for the preparation of a quaternary derivative of the morphinan alkaloid, the process comprising contacting a tertiary N-substituted morphinan alkaloid with an alkyl halide in an anhydrous solvent system, wherein the solvent system comprises an aprotic dipolar solvent with the aprotic dipolar solvent constituting at least 25 wt% of the solvent system.

More Like This:

JP2008501797	Extraction of alkaloids from opium
WO/2002/066031	UTILIZATION OF BUPRENORPHINE IN URINARY INCONTINENCE THERAPY
JP3642576	How to make morphin-6-glucuronide or substituted morphin-6-glucuronide

Inventors:

CANTRELL GARY L (US)
HALVACHS ROBERT E (US)

Application Number:

PCT/US2003/035463

Publication Date:

August 26, 2004

Filing Date:

November 05, 2003

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MALLINCKRODT INC (US)
CANTRELL GARY L (US)
HALVACHS ROBERT E (US)

International Classes:

C07D489/02; C07D489/08; (IPC1-7): C07D489/02

Domestic Patent References:

WO2004005294A2

2004-01-15

Foreign References:

US4176186A

1979-11-27

Download PDF:

View/Download PDF PDF Help

Previous Patent: 1,4-DIAZABICYCLO (3,2,2)NONANE DERIVATIVES, PREPARATION AND THERAPEUTICAL USE THEREOF

Next Patent: CCR1 ANTAGONISTS FOR THE TREATMENT OF I.A. DEMYELINATING INFLAMMATORY DISEASE