PROCESS FOR THE PREPARATION OF α-SUBSTITUTED KETONES AND THEIR APPLICATION IN SYNTHESIS OF PHARMACEUTICALLY ACTIVE COMPOUNDS

Title:

PROCESS FOR THE PREPARATION OF α-SUBSTITUTED KETONES AND THEIR APPLICATION IN SYNTHESIS OF PHARMACEUTICALLY ACTIVE COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/2012/159981

Kind Code:

A3

Abstract:

The present invention relates to a novel one step preparation of 6-methoxy-2-phenyl-tetralone starting from 6-methoxy-tetralone and its use as an intermediate in the synthesis of pharmaceutically active compounds.

Inventors:

GAZIC SMILOVIC IVANA (SI)
SEECHURN CARIN (GB)
COLACOT THOMAS J (GB)

Application Number:

PCT/EP2012/059236

Publication Date:

January 24, 2013

Filing Date:

May 18, 2012

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Assignee:

LEK PHARMACEUTICALS (SI)
GAZIC SMILOVIC IVANA (SI)
SEECHURN CARIN (GB)
COLACOT THOMAS J (GB)

International Classes:

C07C45/68; C07C49/67; C07D295/023

Domestic Patent References:

WO2004063191A1

2004-07-29

Other References:

WAYNE VACCARO ET AL: "Inhibitors of Acyl CoA:Cholesterol Acyltransterase", J. MED. CHEM., vol. 39, 1996, pages 1704 - 1719, XP002658744

Attorney, Agent or Firm:

KUNIC-TESOVIC, Barbara (1526 Ljubljana, SI)

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