Title:
PROCESS FOR PREPARATION OF THIAZOLE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2002/094798
Kind Code:
A1
Abstract:
With the purpose of establishing an industrial production process, the invention provides a process for preparation of thiazole compounds which attains high yield and is excellent in controllability and safety, specifically a process for preparation of thiazole compounds represented by the general formula (I): (I) which comprises reacting a compound (II) with a compound (III) either in an aqueous solvent or in the presence of a base in at least one organic solvent selected from the group consisting of halides, esters, hydrocarbons, ketones, and ethers, or which comprises reacting a compound (II) with a compound (III) in an organic solvent in the presence of a base and subjecting the reaction mixture to (1) addition of an acid and additional reaction or (2) concentration: (II) (III) wherein X is a functional group eliminable by nucleophilic attack.
Inventors:
SATO TAKEHIRO (JP)
MIYAZAKI HIDEKAZU (JP)
HATANO MASAMI (JP)
MATSUI NOBUO (JP)
MATSUSHITA MASAYUKI (JP)
MIYAZAKI HIDEKAZU (JP)
HATANO MASAMI (JP)
MATSUI NOBUO (JP)
MATSUSHITA MASAYUKI (JP)
Application Number:
PCT/JP2002/004990
Publication Date:
November 28, 2002
Filing Date:
May 23, 2002
Export Citation:
Assignee:
NIPPON SODA CO (JP)
SATO TAKEHIRO (JP)
MIYAZAKI HIDEKAZU (JP)
HATANO MASAMI (JP)
MATSUI NOBUO (JP)
MATSUSHITA MASAYUKI (JP)
SATO TAKEHIRO (JP)
MIYAZAKI HIDEKAZU (JP)
HATANO MASAMI (JP)
MATSUI NOBUO (JP)
MATSUSHITA MASAYUKI (JP)
International Classes:
C07D277/30; (IPC1-7): C07D277/30
Foreign References:
| JPH06340643A | 1994-12-13 | |||
| US4468517A | 1984-08-28 | |||
| US5614520A | 1997-03-25 | |||
| DE19623855A1 | 1996-12-19 | |||
| US5137897A | 1992-08-11 | |||
| US5045554A | 1991-09-03 |
Other References:
LEHN JEAN-MARIE ET AL.: "Synthesis of macrobicyclic cryptates incorporating bithiazole, bisimidazole and bipyrimidine binding subunits", TETRAHEDRON LETTERS, vol. 30, no. 17, 1989, pages 2209 - 2212, XP002956338
BAGLEY MARK C. ET AL.: "Total synthesis of the thiopeptide promothiocin A", J. AM. CHEM. SOC., vol. 122, no. 14, 2000, pages 3301 - 3313, XP002905741
GOTTHARDT HANS ET AL., CHEM. BER., vol. 120, no. 6, 1987, pages 1017 - 1022, XP002956339
BAGLEY MARK C. ET AL.: "Total synthesis of the thiopeptide promothiocin A", J. AM. CHEM. SOC., vol. 122, no. 14, 2000, pages 3301 - 3313, XP002905741
GOTTHARDT HANS ET AL., CHEM. BER., vol. 120, no. 6, 1987, pages 1017 - 1022, XP002956339
Attorney, Agent or Firm:
Tokai, Yusaku c/o Nippon Soda Co. Ltd. (2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo, JP)
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