Title:
THE PROCESS FOR PREPARATION OF TOTAL COUMARINS FROM CORTEX FRAXINI AND THEIR USE IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2004/020427
Kind Code:
A1
Abstract:
The present invention discloses a process for preparing total coumarins from Cortex Fraxini, which comprises: a. extracting Cortex Fraxini by the method of water-extracting and alcohol-depositing (50 %-90%) or alcohol-extracting and alcohol-depositing (50 %-90%) or alcohol-extracting (70 %-95%) to obtain a extract; b. subjecting the extract to the temperature between 4-12 °C for 8-24 hours to form a deposit; c. filtering the resulting deposit and drying, resulting the total coumarins from Cortex Fraxini . The invention also relates to the use of total coumarins in Cortex Fraxini in manufacturing medicines for treating acute or chronic gout diseases. The present invention also discloses a process for extracting esculin from total coumarins from Cortex Fraxini, and the use of esculin in manufacturing medicines for treating acute or chronic gout diseases.
Inventors:
YANG ANDONG (CN)
ZHAO JUNNING (CN)
ZHAO JUNNING (CN)
Application Number:
PCT/CN2003/000191
Publication Date:
March 11, 2004
Filing Date:
March 17, 2003
Export Citation:
Assignee:
SICHUAN DIKANG INDUSTRY HOLDIN (CN)
YANG ANDONG (CN)
ZHAO JUNNING (CN)
YANG ANDONG (CN)
ZHAO JUNNING (CN)
International Classes:
A61K31/37; A61K36/00; A61P19/06; C07D311/08; (IPC1-7): C07D311/08; A61K31/37; A61K35/78; A61P19/06
Foreign References:
| JPS4111272B1 | ||||
| US5376372A | 1994-12-27 | |||
| CN1250664A | 2000-04-19 | |||
| CN1101259A | 1995-04-12 |
Other References:
JIANGSU XIN YIXUEYUAN: "Zhongyao da Cidian", 1986, SHANGHAI TECHNOLOGY PRESS, pages: 1767 - 1768
Attorney, Agent or Firm:
CHINA TRADEMARK AND PATENT LAW OFFICE (14 Yuetan Nanjie Street Xicheng District, Beijing 5, CN)
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