Title:
PROCESS FOR THE PREPARATION OF UNSYMMETRICALLY SUBSTITUTED BIPHENYL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2008087656
Kind Code:
B1
Abstract:
A process for the preparation of unsymmetrical biaryl compounds of Formula (I) wherein, R is alkyl, R' is cyano, protected or unprotected tetrazole, or Formula (a) wherein, R" is alkyl, aryl, aralkyl or alkoxy, said process comprising, reacting Grignard reagent of Formula (II) wherein, R is alkyl; X is halogen with an aryl halide of Formula (III) wherein, X is halogen; R' is a cyano, protected or unprotected tetrazole, or Formula (a) wherein, R" is alkyl, aryl, aralkyl or alkoxy in a suitable solvent in the presence of a palladium catalyst and a ligand and Lewis acid as a co catalyst.
Inventors:
LAL BANSI (IN)
BAPAT CHINTAMANI (IN)
CHATURVEDI ROHIT (IN)
TADE KAILASH (IN)
MULLA DILAWAR (IN)
NARKHEDE NISHIKANT (IN)
BAPAT CHINTAMANI (IN)
CHATURVEDI ROHIT (IN)
TADE KAILASH (IN)
MULLA DILAWAR (IN)
NARKHEDE NISHIKANT (IN)
Application Number:
PCT/IN2008/000018
Publication Date:
November 06, 2008
Filing Date:
January 14, 2008
Export Citation:
Assignee:
CALYX CHEMICALS AND PHARMACEUT (IN)
LAL BANSI (IN)
BAPAT CHINTAMANI (IN)
CHATURVEDI ROHIT (IN)
TADE KAILASH (IN)
MULLA DILAWAR (IN)
NARKHEDE NISHIKANT (IN)
LAL BANSI (IN)
BAPAT CHINTAMANI (IN)
CHATURVEDI ROHIT (IN)
TADE KAILASH (IN)
MULLA DILAWAR (IN)
NARKHEDE NISHIKANT (IN)
International Classes:
C07D257/04; C07C251/24; C07C253/30; C07C255/50
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