Title:
PROCESS FOR PREPARING CARBOXYLIC ESTERS OF OPTICALLY ACTIVE 1-PERFLUOROALKYLATED ALCOHOLS, OPTICALLY ACTIVE 1-PERFLUOROALKYLATED ALCOHOLS AND PROCESS FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2001/025183
Kind Code:
A1
Abstract:
Optically active 1-perfluoroalkylated alcohols can be prepared by subjecting a 1-perfluoroalkylated unsaturated ester to asymmetric hydrogenation with an optically active ruthenium complex catalyst to thereby obtain a carboxylic ester of 1-perfluoroalkylated alcohol as represented by general formula (III) (wherein R¿f? is perfluoroalkyl; and R?1¿ and R?2¿ are each hydrogen, alkyl, aryl, or the like), and hydrolyzing this ester to thereby obtain an optically active 1-perfluoroalkylated alcohol corresponding thereto. The present invention provides optically active 1-perfluoroalkylated alcohols such as 1-trifluoromethylated alcohols useful as important intermediates for the preparation of medicines, agricultural chemicals, liquid crystals, or other functional or physiologically active materials; precursors thereof; and a process for preparing the same easily in high yield.
Inventors:
ISEKI KATSUHIKO (JP)
KUROKI YOSHICHIKA (JP)
ASADA DAISUKE (JP)
SAKAMAKI YUKO (JP)
KUROKI YOSHICHIKA (JP)
ASADA DAISUKE (JP)
SAKAMAKI YUKO (JP)
Application Number:
PCT/JP2000/006866
Publication Date:
April 12, 2001
Filing Date:
October 02, 2000
Export Citation:
Assignee:
DAIKIN IND LTD (JP)
ISEKI KATSUHIKO (JP)
KUROKI YOSHICHIKA (JP)
ASADA DAISUKE (JP)
SAKAMAKI YUKO (JP)
ISEKI KATSUHIKO (JP)
KUROKI YOSHICHIKA (JP)
ASADA DAISUKE (JP)
SAKAMAKI YUKO (JP)
International Classes:
C07B53/00; C07B61/00; C07C27/02; C07C29/09; C07C31/38; C07C67/283; C07C69/145; C07C69/62; (IPC1-7): C07C67/283; C07B61/00; C07C27/02; C07C27/04; C07C31/125; C07C69/145
Foreign References:
| JPH1112229A | 1999-01-19 | |||
| JPH10195027A | 1998-07-28 | |||
| JPH09301929A | 1997-11-25 | |||
| EP0039830A1 | 1981-11-18 |
Other References:
KOENIG KARL E. ET AL.: "Asymmetric hydrogenation of germinal-substituted vinyl acetates", J. ORG. CHEM., vol. 45, no. 12, 1980, pages 2362 - 2365, XP002933995
KUROKI Y. ET AL.: "Enantioselective synthesis of 1,1,1-trifluoroalkan-2-ols by ruthenium-catalyzed hydrogenation", TETRAHEDRON LETTERS, vol. 41, 2000, pages 4603 - 4607, XP002933996
KUROKI Y. ET AL.: "Enantioselective synthesis of 1,1,1-trifluoroalkan-2-ols by ruthenium-catalyzed hydrogenation", TETRAHEDRON LETTERS, vol. 41, 2000, pages 4603 - 4607, XP002933996
Attorney, Agent or Firm:
Osaka, Hiromu (Shibazaki-cho 2-chome Tachikawa-shi Tokyo, JP)
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