Title:
PROCESS FOR PREPARING N,N,6- TRIMETHYL-2 -(4-METHYLPHENYL)- IMIDAZO-[1,2-A] -PYRIDINE-3- ACETAMIDE AND SALTS THEREOF
Document Type and Number:
WIPO Patent Application WO2000008021
Kind Code:
A3
Abstract:
The process comprises reducing the hydroxyester of formula (X) by making it react in DMF successively with an imine salt of formula (XIII) formed "in situ" with thionyl chloride and dimethylformamide, and subsequent reduction with an appropriate reducer in order to form the ester of formula (XII) which is then reacted with dimethylamine in a polyhydroxylated solvent medium in appropriate temperature conditions.
Inventors:
LABRIOLA RAFAEL (AR)
Application Number:
PCT/ES1999/000250
Publication Date:
July 06, 2000
Filing Date:
August 04, 1999
Export Citation:
Assignee:
SINT QUIMICA SA (ES)
LABRIOLA RAFAEL (AR)
LABRIOLA RAFAEL (AR)
International Classes:
A61K31/415; A61K31/435; C07D471/04; (IPC1-7): C07D471/04
Foreign References:
| FR2600650A1 | 1987-12-31 |
Other References:
GEORGE P ET AL: "Le zolpidem: Un nouvel hypnotique de structure imidazo[1,2-alpha]pyridine", ACTUAL. CHIM. THÉR.; 18(RECONTRES INT. CHIM. THER. 26 TH, 1990), 1991, pages 215 - 239, XP002900936
GEORGE P ET AL: "Imidazopyridines: Towards novel hypnotic and anxiolytic drugs", IL FARMACO, vol. 46, no. 1 suppl., 1991, pages 277 - 288, XP002900937
TRAPANI G ET AL: "Synthesis and Binding Affinity of 2-Phenylimidazo[1,2-alpha]pyridine Derivatives for both Central and Peripheral Benzodiazepine Receptors. A New Series of High-Affinity and Selective Ligands for the Peripheral Type", J. MED. CHEM., vol. 40, 1997, pages 3109 - 3118, XP002900938
GEORGE P ET AL: "Imidazopyridines: Towards novel hypnotic and anxiolytic drugs", IL FARMACO, vol. 46, no. 1 suppl., 1991, pages 277 - 288, XP002900937
TRAPANI G ET AL: "Synthesis and Binding Affinity of 2-Phenylimidazo[1,2-alpha]pyridine Derivatives for both Central and Peripheral Benzodiazepine Receptors. A New Series of High-Affinity and Selective Ligands for the Peripheral Type", J. MED. CHEM., vol. 40, 1997, pages 3109 - 3118, XP002900938
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