Title:
PROCESS FOR PRODUCIGN OPTICALLY ACTIVE ETHYL (3R,5S,6E)-7-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)QUINOLIN-3-YL]-3,5-DIHYDROXY-6-HEPTENOATE
Document Type and Number:
WIPO Patent Application WO/2002/030903
Kind Code:
A1
Abstract:
A process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate which comprises optically resolving, at a high efficiency, a mixture of optical isomers of the compound, characterized in that a packing comprising a support and cellulose tris(4-chlorophenylcarbamate) deposited thereon in a specific proportion is used to chromatographically isolate the target isomer under such conditions as to result in a specific retention volume.
Inventors:
ONISHI ATSUSHI (JP)
MURAZUMI KOICHI (JP)
TACHIBANA KOZO (JP)
MURAZUMI KOICHI (JP)
TACHIBANA KOZO (JP)
Application Number:
PCT/JP2001/009000
Publication Date:
April 18, 2002
Filing Date:
October 12, 2001
Export Citation:
Assignee:
DAICEL CHEM (JP)
NISSAN CHEMICAL IND LTD (JP)
ONISHI ATSUSHI (JP)
MURAZUMI KOICHI (JP)
TACHIBANA KOZO (JP)
NISSAN CHEMICAL IND LTD (JP)
ONISHI ATSUSHI (JP)
MURAZUMI KOICHI (JP)
TACHIBANA KOZO (JP)
International Classes:
A61K31/47; B01D15/08; B01D15/38; B01J20/26; B01J20/281; B01J20/29; B01J20/32; C07B57/00; C07D215/04; C07D215/14; B01D15/18; (IPC1-7): C07D215/14; B01D15/08; C07B57/00; G01N30/48
Foreign References:
| EP0747341A1 | 1996-12-11 |
Other References:
NAGAMATSU S. ET AL.: "Chiral separation of a pharmaceutical intermediate by a simulated moving bed process", J. CHROMATOGR. A., vol. 832, 1999, pages 55 - 65, XP004156166
See also references of EP 1334967A4
See also references of EP 1334967A4
Attorney, Agent or Firm:
Fukumura, Naoki (Nishi-Shinjuku 7-chome Shinjuku-ku, Tokyo, JP)
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