Title:
PROCESS FOR PRODUCING 1-(4-PYRIDYL)-4-PIPERIDONE
Document Type and Number:
WIPO Patent Application WO/2003/095446
Kind Code:
A1
Abstract:
A process for producing 1-(4-pyridyl)-4-piperidone which comprises converting 4-aminopyridine, which is inexpensive, as a starting material into a nitrogenous dicarboxylic acid or an ester thereof, subsequently causing the acid or ester to undergo intramolecular condensation to form a nitrogenous cyclic ß-keto form, optionally conducting hydrolysis, and then conducting decarboxylation; and an intermediate for the production which is represented by the following formula (III). Thus, 1-(4-pyridyl)-4-piperidone having a high purity can be industrially obtained at low cost in a high yield under mild reaction conditions through a simple purification step while diminishing by-product generation. (III) (In the formula, R3 represents hydrogen or C1-4 alkyl.)
Inventors:
NISHIDA HIDEMITSU (JP)
Application Number:
PCT/JP2003/005775
Publication Date:
November 20, 2003
Filing Date:
May 08, 2003
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
NISHIDA HIDEMITSU (JP)
NISHIDA HIDEMITSU (JP)
International Classes:
C07D213/74; (IPC1-7): C07D401/04
Domestic Patent References:
| WO1999052895A1 | 1999-10-21 | |||
| WO1997036899A1 | 1997-10-09 | |||
| WO1997003072A1 | 1997-01-30 |
Foreign References:
| US5753659A | 1998-05-19 | |||
| JPS5498771A | 1979-08-03 |
Other References:
"Dai Yuki Kagaku", vol. 16, 30 October 1965, KABUSHIKI KAISHA ASAKURA SHOTEN, article "Fukusokan-shiki kagobutsu III", pages: 108 - 111, XP002970429
Attorney, Agent or Firm:
Watanabe, Mochitoshi (12-5 Iwamoto-cho 2-chom, Chiyoda-ku Tokyo, JP)
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