PROCESS FOR PRODUCING 4-CHLOROAZETIDINONE COMPOUND

WIPO Patent Application WO/2010/095617

A1

Disclosed is a process for producing a 4-chloroazetidinone compound, which is a compound useful as an intermediate for the synthesis of a carbapenem antibiotic, with high efficiency and in a high yield.  Also disclosed is an intermediate which can be used as a starting material in the process. Specifically disclosed is a process for producing a 4-chloroazetidinone compound represented by general formula (1) [wherein R1 represents a hydrogen atom or a protective group for a hydroxy group] by chlorinating the fourth position in a 4-dithioazetidinone compound represented by general formula (2) [wherein R1 is as defined in above; and R3 represents a heterocyclic group].

TANAKA HIDEO (JP)
KUROBOSHI MANABU (JP)
ITO OSAMU (JP)
YUASA HIROAKI (JP)

PCT/JP2010/052285

August 26, 2010

February 16, 2010

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OTSUKA CHEMICAL CO LTD (JP)
TANAKA HIDEO (JP)
KUROBOSHI MANABU (JP)
ITO OSAMU (JP)
YUASA HIROAKI (JP)

C07F7/18; C07D499/32; C25B3/06

JPS5799589A	1982-06-21
JPS57183793A	1982-11-12
JPS63188684A	1988-08-04
JPS588084A	1983-01-18
JPH0225914B2	1990-06-06

MARCO ALPEGIANI ET AL.: "DESULFURATIVE APPROACHES TO PENEM ANTIBIOTICS. II. 4-ACYLDITHIOAZETIDIN-2-ONES FROM PENICILLIN DERIVED SULFENIMIDES, THIOLSULFONATES AND DISULFIDES.", TETRAHEDRON LETTERS, vol. 24, no. 15, 1983, pages 1627 - 1630
MARCO ALPEGIANI ET AL.: "REARRANGEMENT OF unsym-AZETIDINONE DISULFIDES TO 2p-(THIO- SUBSTITUTED METHYL)PENAMS", TETRAHEDRON LETTERS, vol. 31, no. 24, 1990, pages 3509 - 3512

SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)

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