Title:
PROCESS FOR PRODUCING ALDOHEXOPYRANOSE INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2004/106352
Kind Code:
A1
Abstract:
A process for producing a tetra-O-acetylaldohexopyranose represented by the formula (VI) which comprises reacting a penta-O-acetylaldohexopyranose represented by the following formula (V) with a mixture of a hydrazine compound represented by R1R2NNH2 and an organic acid represented by R3COOH to selectively remove an acetyl group. In the reaction scheme, Ac represents acetyl; X represents -O- or -S-; R1 represents hydrogen or C1-6 alkyl and R2 represents C1-6 alkyl, etc., or R1 and R2 are bonded to each other and represent, in cooperation with the hydrazine group, optionally substituted N-aminopyrrolidine, etc.; and R3 represents C1-6 alkyl.
Inventors:
KAKINUMA HIROYUKI (JP)
SATO MASAKAZU (JP)
ASANUMA HAJIME (JP)
TOMISAWA KAZUYUKI (JP)
SATO MASAKAZU (JP)
ASANUMA HAJIME (JP)
TOMISAWA KAZUYUKI (JP)
Application Number:
PCT/JP2004/007556
Publication Date:
December 09, 2004
Filing Date:
May 26, 2004
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
KAKINUMA HIROYUKI (JP)
SATO MASAKAZU (JP)
ASANUMA HAJIME (JP)
TOMISAWA KAZUYUKI (JP)
KAKINUMA HIROYUKI (JP)
SATO MASAKAZU (JP)
ASANUMA HAJIME (JP)
TOMISAWA KAZUYUKI (JP)
International Classes:
C07H1/00; C07H13/06; (IPC1-7): C07H1/00; C07H13/06
Foreign References:
| JPH07109286A | 1995-04-25 |
Other References:
KHAN R. ET AL: "Regioselective Deacetylation of Fully Acetylated Mono- and Di-saccharides with Hydrazine Hydrate", AM. J. OF CHEMISTRY, vol. 49, no. 3, 1996, pages 293 - 298
Attorney, Agent or Firm:
Satori, Soichi c/o TAISHO PHARMACEUTICAL CO. LTD. (INTELLECTUAL PROPERTY DIVISION, 24-1, Takada 3-chom, Toshima-ku Tokyo 33, JP)
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