PROCESS FOR PRODUCING BICALUTAMIDE AND METHOD OF PURIFYING INTERMEDIATE THEREFOR

WIPO Patent Application WO/2005/037777

A1

A process for producing bicalutamide, which is represented by the formula (4), (4) which comprises: a step (A) in which the compound represented by the formula (1) is reacted with a peroxycarboxylic acid to obtain the compound (2) represented by the formula (2); (2) a step (B) in which the compound (2) is reacted with 4-fluorothiophenol to obtain crude crystals of the compound (3) represented by the formula (3) and the crude crystals are dissolved in a solvent and crystallized therefrom to obtain purified crystals of the compound (3); and a step (C) in which the purified crystals of the compound (3) are reacted with a peroxycarboxylic acid to obtain bicalutamide. Also provided is a method of purifying crystals of the compound (3), which comprises dissolving crude crystals of the compound (3) in a solvent and crystallizing it.

SHINTAKU TETSUYA (JP)
KATSURA TADASHI (JP)
SUGI KIYOSHI (JP)
ITAYA NOBUSHIGE (JP)

PCT/JP2004/015669

April 28, 2005

October 15, 2004

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SUMITOMO CHEMICAL CO (JP)
SHINTAKU TETSUYA (JP)
KATSURA TADASHI (JP)
SUGI KIYOSHI (JP)
ITAYA NOBUSHIGE (JP)

C07C315/02; C07C315/06; C07C317/46; C07C319/28; C07C323/62; (IPC1-7): C07C315/02; C07C315/06; C07C317/46; C07C319/28; C07C323/62

WO2003053920A1	2003-07-03
WO2002024638A1	2002-03-28
WO2001000608A1	2001-01-04
WO2001028990A2	2001-04-26
WO2002024638A1	2002-03-28
WO2003053920A1	2003-07-03

HOWARD TUCKER ET AL., J. MED. CHEM., vol. 31, 1988, pages 954 - 959
See also references of EP 1679306A4

Enomoto, Masayuki c/o Sumitomo Chemical Intellectual (Property Service Limited, 5-33, Kitahama 4-chome, Chuo-k, Osaka-shi Osaka, JP)

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